THE IMPORTANCE OF SURGERY TO NON-SMALL CELL-CARCINOMA OF LUNG WITH MEDIASTINAL LYMPH-NODE METASTASIS
THE IMPORTANCE OF SURGERY TO NON-SMALL CELL-CARCINOMA OF LUNG WITH MEDIASTINAL LYMPH-NODE METASTASIS
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DOI：
10.1016/s0003-4975(10)64717-0
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发表时间：
1988-12-01
影响因子：
4.6
通讯作者：
SUEMASU, K
中科院分区：
文献类型：
--
作者：
NARUKE, T;GOYA, T;SUEMASU, K
在过去的25年里，1,654名非小细胞癌患者在日本东京国立癌症中心医院接受了切除术。本文对肺切除加纵隔淋巴结清扫与不加纵隔淋巴结清扫患者的5年生存率进行了比较研究。N2 MO病426例，占25.8%。其中345例接受了肺切除术和纵隔淋巴结清扫术。本组5年生存率为15.9%（T1 N2 MO，30.0%; T2 N2 M0，14.5%; T3 N2 MO，12.9%）。其余81例未行纵隔淋巴结清扫，5年生存率为6.7%。在426例N2 MO病患者中，242例为选择性患者，接受了根治性手术，总的5年生存率为19.2%。其中鳞癌66例，5年生存率为30.8%;腺癌153例，5年生存率为16.0%;大细胞癌14例，5年生存率为12.8%;腺鳞癌9例，5年生存率为0。为了提高最终结果，重要的是要尽可能多地进行纵隔淋巴结清扫术。必须考虑组织学细胞类型和肿瘤状态。
In the past 25 years, 1,654 patients with non-small cell cancer underwent resection at National Cancer Center Hospital , Tokyo Japan. A comparative study has been made of 5-year survival of patients who had pulmonary resection with and without mediastinal lymph node dissection. There were 426 patients (25.8% of the total) with N2 MO disease. Of these, 345 underwent pulmonary resection with mediastinal lymph node dissection. The 5-year survival in this group was 15.9% (T1 N2 MO, 30.0%; T2 N2 M0, 14.5; and T3 N2 MO, 12.9%). In the remaining 81 patients, who did not have mediastinal lymph node dissection, 5-year survival was 6.7%. Of the 426 patients with N2 MO disease, 242 were select patients who underwent a curative operation with an over-all 5-year survival of 19.2%. Sixty-six of them had squamous cell carcinoma and a 5-year survival of 30.8%; 153 had adenocarcinoma and a survival of 16.0%; 14 had large cell carcinoma and a survival of 12.8%; and 9 had adeno-squamous cell carcinoma, and none survived 5 years. To improve the end results, it is important to perform as many curative operations with mediastinal lymph node dissection as possible. Histological cell type and tumor status must be taken into consideration.