Asthma caused by occupational exposures is common - a systematic analysis of estimates of the population-attributable fraction.
Asthma caused by occupational exposures is common - a systematic analysis of estimates of the population-attributable fraction.
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DOI：
10.1186/1471-2466-9-7
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发表时间：
2009-01-29
影响因子：
3.1
通讯作者：
Blanc, Paul D
中科院分区：
文献类型：
--
作者：
Toren, Kjell;Blanc, Paul D
背景：这篇论文的目的是强调哮喘职业归因风险的新数据。尽管疾病暴发有很好的记录，并认识到许多特定的致病因素，但与成人哮喘的其他原因相比，职业性暴露以前所起的作用相当小。近年来，人们越来越多地认识到与工作相关的暴露导致哮喘的潜在重要性。方法：我们检索了1999年6月至2007年12月期间的Pub Med。我们从7个基于总体的样本中确定了6个纵向的一般人群研究、3个病例对照研究和8个横断面分析。为了进行综合分析，我们在之前的综述中增加了1999年前的10项估计。结果：纵向研究表明，16.3%的成人哮喘发病是由职业暴露引起的。在所有纳入研究的总体综合中，总体中位数PAR值为17.6%。结论：临床医生在评估处于工作年龄的哮喘患者时应考虑职业史。在社会层面上，这些发现强调了采取进一步预防行动的必要性，以减少职业接触引起哮喘的药物。
BACKGROUND: The aim of this paper is to highlight emerging data on occupational attributable risk in asthma. Despite well documented outbreaks of disease and the recognition of numerous specific causal agents, occupational exposures previously had been relegated a fairly minor role relative to other causes of adult onset asthma. In recent years there has been a growing recognition of the potential importance of asthma induced by work-related exposuresMETHODS: We searched Pub Med from June 1999 through December 2007. We identified six longitudinal general population-based studies; three case-control studies and eight cross-sectional analyses from seven general population-based samples. For an integrated analysis we added ten estimates prior to 1999 included in a previous review.RESULTS: The longitudinal studies indicate that 16.3% of all adult-onset asthma is caused by occupational exposures. In an overall synthesis of all included studies the overall median PAR value was 17.6%.CONCLUSION: Clinicians should consider the occupational history when evaluating patients in working age who have asthma. At a societal level, these findings underscore the need for further preventive action to reduce the occupational exposures to asthma-causing agents.