Endocrine changes during pregnancy in a patient with homozygous familial hypobetalipoproteinemia.
Endocrine changes during pregnancy in a patient with homozygous familial hypobetalipoproteinemia.
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纯合子家族性低β脂蛋白血症患者妊娠期间的内分泌变化。
DOI：
10.1056/nejm198602273140906
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Carr,BR
中科院分区：
文献类型：
--
作者：
ParkerJr,CR;Illingworth,DR;Bissonnette,J;Carr,BR
人类妊娠的特征是产生大量孕酮和雌激素，孕酮主要由妊娠中期和妊娠晚期的胎盘提供，雌激素主要由胎儿和母体肾上腺皮质合成的类固醇前激素在胎盘中形成。低密度脂蛋白（LDL）中携带的胆固醇通过为许多组织中的类固醇激素形成提供底物，在类固醇生成中发挥重要作用。12345678根据现有证据，血浆LDL胆固醇似乎可能是正常人类妊娠期间孕酮和雌激素的主要前体。. . .
HUMAN pregnancy is characterized by the production of massive quantities of progesterone, which is supplied primarily by the placenta during the second and third trimesters, and of estrogens, which are formed in the placenta from steroid prehormones synthesized principally in the fetal, but also in the maternal, adrenal cortexes. The cholesterol carried in low-density lipoproteins (LDLs) serves an important role in steroidogenesis by supplying substrate for steroid-hormone formation in a number of tissues.12345678On the basis of the available evidence, it seems likely that plasma LDL cholesterol is the major precursor of both progesterone and estrogens during normal human pregnancy. . . .