Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.
Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.
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文库的文库：合成组合文库设计和“药效基团”基序筛选的方法。
DOI：
10.1073/pnas.92.12.5426
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发表时间：
1995
影响因子：
11.1
通讯作者：
Lebl,M
中科院分区：
文献类型：
--
作者：
Sepetov,NF;Krchnák,V;Stanková,M;Wade,S;Lam,KS;Lebl,M
描述了合成组合文库的构建，其允许生成基序文库而不是化合物文库。合成了基于该策略的肽库，并用模型靶链霉亲和素和抗β-内啡肽抗体进行筛选。屏幕导致观察到预期的图案提供证据的有效性建议的方法。
Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-beta-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.