Physiological Changes in Androgen Plasma Levels with Elapsing of Time from Castration in Adult Male Rats
Physiological Changes in Androgen Plasma Levels with Elapsing of Time from Castration in Adult Male Rats
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成年雄性大鼠去势后血浆雄激素水平随时间的生理变化
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
F. Dessì
中科院分区：
文献类型：
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作者：
S. Andò;S. Aquila;E. Beraldi;M. Canonaco;M. L. Panno;A. Valenti;F. Dessì
在本研究中，我们研究了阉割后5天（II组）、7周（III组）和11周（IV组）成年雄性大鼠血浆中脱氢表雄酮（DHEA）、雄烯二酮（delta 4）、睾酮(T)和双氢睾酮（DHT）水平的变化。在大约60日龄的大鼠中进行了相同的激素测定，这些大鼠接受了假手术切除睾丸（I组）。我们的数据显示，睾丸切除术后5天（II组），与假手术大鼠相比，δ 4、T和DHT下降。(I组：δ 4: 83.3 +/- 14.9 (SEM) ng/dl (n = 12)；T: 435.32 +/- 51.45 (n = 12)；DHT: 51.47 +/- 6.54 (n = 12)；II组：δ 4: 44.81 +/- 6.09 (n = 12) P = 0.05；T: 25.54 +/- 2.88 (n = 12), P < 0.01；DHT: 12.9 +/- 2.51 (n = 12) P < 0.01)。术后7周T和DHT仍显著降低（III组：T: 54.37 +/- 12.21, n = 16） （P < 0.01）， DHT: 33.22 +/- 4.49 (n = 16) P < 0.01)，术后11周各激素均较假手术大鼠显著降低。（IV组）δ 4: 32.01 +/- 5.7 (n = 10) P < 0.01; δ 4: 27.29 +/- 7.05 (n = 10) P < 0.01；DHT: 29.03: 5.34 (n = 10), P < 0.01)。（摘要删节250字）
In the present study we investigated in adult male rats the effects of castration on Dehydroepiandrosterone (DHEA), Androstenedione (delta 4), Testosterone (T) and Dihydrotestosterone (DHT) plasma levels: five days (group II), seven weeks (group III) and eleven weeks (group IV) after orchiectomy. The same hormone assays were performed in rats approximately 60 days of age which underwent a sham-operation for orchiectomy (group I). Our data show that five days following orchiectomy (group II) delta 4, T and DHT were decreased with respect to sham-operated rats. (Group I: delta 4: 83.3 +/- 14.9 (SEM) ng/dl (n = 12); T: 435.32 +/- 51.45 (n = 12); DHT: 51.47 +/- 6.54 (n = 12); Group II: delta 4: 44.81 +/- 6.09 (n = 12) P = 0.05; T: 25.54 +/- 2.88 (n = 12) P less than 0.01; DHT: 12.9 +/- 2.51 (n = 12) P less than 0.01). Seven weeks afterwards T and DHT remained significantly lower (group III: T: 54.37 +/- 12.21, n = 16) (P less than 0.01; DHT: 33.22 +/- 4.49 (n = 16) P less than 0.01) while eleven weeks after all steroids were significantly decreased with respect to the values observed in sham-operated rats. (Group IV) delta 4: 32.01 +/- 5.7 (n = 10) P less than 0.01: T: 27.29 +/- 7.05 (n = 10) P less than 0.01; DHT: 29.03: 5.34 (n = 10) P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)