Design and synthesis of telomestatin derivatives and their inhibitory activity of telomerase
Design and synthesis of telomestatin derivatives and their inhibitory activity of telomerase
复制标题
DOI：
10.3987/com-06-s(o)38
复制
发表时间：
2006-12
期刊：
影响因子：
0.6
通讯作者：
K. Nagasawa;Masayuki Tera;Y. Sohtome;Hiromi Ishizuka;T. Doi;M. Takagi;K. Shin‐ya
中科院分区：
文献类型：
--
作者：
K. Nagasawa;Masayuki Tera;Y. Sohtome;Hiromi Ishizuka;T. Doi;M. Takagi;K. Shin‐ya
设计并合成了具有大环双酰胺结构的端粒抑制素衍生物2a-2c。其中一个化合物（2a）对端粒酶有抑制活性，IC 50为2 μM。
Telomestatin derivatives of 2a-2c, which have macrocyclic bisamide structure, were designed and synthesized. One of these compounds (2a) showed inhibitory activity of telomerase with an IC 50 of 2 μM.