Overview of TNF Superfamily: A Chest Full of Potential Therapeutic Targets
Overview of TNF Superfamily: A Chest Full of Potential Therapeutic Targets
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DOI：
10.1007/978-0-387-89520-8_1
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发表时间：
2009-01-01
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影响因子：
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通讯作者：
Grewal, Iqbal S.
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文献类型：
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作者：
Grewal, Iqbal S.
自25年前发现肿瘤坏死因子TNF α以来，TNF超家族已发展成为一个由20多个成员组成的相关蛋白质大家族，通过30多个受体进行信号传导。该超家族的成员具有广泛的组织分布，并发挥重要作用，从调节正常生物过程如免疫应答、造血和形态发生到它们在肿瘤发生、移植排斥、败血性休克、病毒复制、骨吸收和自身免疫中的作用。因此，已经开发了许多利用TNF超家族成员的效力来治疗人类疾病的方法。事实上，TNF和TNF激动分子已经在美国和其他国家被批准用于人。许多其他TNF家族成员显示出用于多种治疗应用的前景，包括癌症、传染病、移植和自身免疫。本章将概述TNF超家族在人类治疗中的应用。
Since the discovery of tumor necrosis factor TNF alpha about 25 years ago, TNF superfamily has grown to a large family of related proteins consisting of over 20 members that signal through over 30 receptors. Members of this superfamily have wide tissue distribution and play important roles ranging from regulation of the normal biological processes such as immune responses, hematopoiesis and morphogenesis to their role in tumorigenesis, transplant rejection, septic shock, viral replication, bone resorption and autoimmunity. Thus, many approaches to harness the potency of TNF superfamily members to treat human diseases have been developed. Indeed, TNF and TNF agonistic molecules have been approved for human use in the United States and other countries, Many other TNF family members show promise for several therapeutic applications, including cancer, infectious disease, transplantation and autoimmunity. This chapter will give overview of TNF superfamily for exploitation for therapeutic use in humans.