An integrative review of factors associated with telomere length and implications for biobehavioral research.
An integrative review of factors associated with telomere length and implications for biobehavioral research.
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与端粒长度相关的因素的综合回顾及其对生物行为研究的影响。
DOI：
10.1097/nnr.0000000000000009
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发表时间：
2014-01
期刊：
影响因子：
2.5
通讯作者：
Jackson-Cook CK
中科院分区：
文献类型：
--
作者：
Starkweather AR;Alhaeeri AA;Montpetit A;Brumelle J;Filler K;Montpetit M;Mohanraj L;Lyon DE;Jackson-Cook CK
虽然端粒缩短是衰老的自然部分，但现在有大量研究表明，社会心理，环境和行为因素与端粒长度变化之间存在关系。将端粒测量纳入生物行为研究时需要考虑这些因素。本文简要总结了端粒生物学的已知事实，并对当前人类研究进行了综合回顾，这些研究评估了社会心理，环境或行为因素与端粒长度之间的关系。一个综合性的审查，以检查人类的研究，重点是心理，环境和行为因素影响端粒长度和端粒酶活性的电子数据库PubMed/Medline和CINAHL从2003年至今。除了已知的与端粒长度相关的个体因素外，综合评价的结果表明，还应测量感知压力、童年逆境、重度抑郁症、教育程度、体力活动和睡眠时间。已经证明多种因素影响端粒长度。为了进一步了解端粒长度在健康和疾病风险中的作用，进一步阐明导致端粒缩短的机制将非常重要。
Although telomere shortening occurs as a natural part of aging, there is now a robust body of research that suggests that there is a relationship between psychosocial, environmental, and behavioral factors and changes in telomere length. These factors need to be considered when integrating telomere measurement in biobehavioral research studies. This article provides a brief summary of the known facts about telomere biology and an integrative review of current human research studies that assessed relationships between psychosocial, environmental, or behavioral factors and telomere length. An integrative review was conducted to examine human research studies that focused on psychosocial, environmental, and behavioral factors affecting telomere length and telomerase activity using the electronic databases PubMed/Medline and CINAHL from 2003 to the present. In addition to the known individual factors that are associated with telomere length, the results of the integrative review suggest that perceived stress, childhood adversities, major depressive disorder, educational attainment, physical activity, and sleep duration should also be measured. Multiple factors have been shown to affect telomere length. To advance understanding of the role of telomere length in health and disease risk, it will be important to further elucidate the mechanisms that contribute to telomere shortening.