Juvenile chronic granulocytic leukemia: emphasis on cutaneous manifestations and underlying neurofibromatosis.
Juvenile chronic granulocytic leukemia: emphasis on cutaneous manifestations and underlying neurofibromatosis.
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青少年慢性粒细胞白血病：强调皮肤表现和潜在的神经纤维瘤病。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
Robert D. Koler
中科院分区：
文献类型：
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作者：
Jane A. Mays;R. C. Neerhout;G. Bagby;Robert D. Koler
本文报告五例幼年型慢性粒细胞白血病。两名患者有多个与von Recklinghausen神经纤维瘤病相一致的乳房白斑，三名患者有皮肤黄色瘤。复发性皮肤白血病浸润，注意到两名患者。所有5例患者的临床过程的特点是反复呼吸道症状和肺浸润，其中3例对抗白血病治疗有反应。化疗控制了症状，但不影响最终的死亡结局。
Five patients with juvenile chronic granulocytic leukemia are described. Two patients had multiple cafe-au-lait spots compatible with von Recklinghausen's neurofibromatosis, and three had cutaneous xanthomata. Recurrent cutaneous leukemic infiltrates were noted in two patients. The clinical course of all five patients was characterized by recurrent respiratory symptoms and pulmonary infiltrates that responded to antileukemic therapy in three. Chemotherapy controlled the symptoms but did not influence the eventually fatal outcome.