Sleep homeostasis: finding Odysseus among the mnesteres.
Sleep homeostasis: finding Odysseus among the mnesteres.
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睡眠稳态：在记忆中寻找奥德修斯。
DOI：
10.1093/sleep/33.9.1131
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发表时间：
2010
期刊：
影响因子：
5.6
通讯作者：
Veasey,Sigrid
中科院分区：
文献类型：
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作者：
Veasey,Sigrid
睡眠，卷。 33，第 9 期，2010 1132 评论——维西剥夺。从这种方法中，我们可以得出结论，许多髓磷脂分子、膜和细胞骨架蛋白的基因受到皮质酮依赖性方式的强制觉醒的抑制。如果我们想回答哪些过程被长期睡眠限制所扰乱，或者为什么我们需要睡眠，肾上腺必须保持完整，而 Mackiewicz 等人使用的方法 13 ，通过多次睡眠剥夺的持续时间来提供不同水平的稳态驱动，将是更好的选择。让我们在寻找睡眠稳态基因时像 Penelope 一样谨慎。重点蛋白质组学筛选（针对此 mRNA 阵列列表）是否支持这些基因参与睡眠稳态？ Homer1 或任何其他候选基因是否对睡眠不足表现出剂量依赖性反应，从而预测了几种小鼠品系的稳态驱动？随着稳态驱动力的增加，该基因在年轻人中是否会增加更大程度，并且这种反应是否会随着年龄的增长而随着稳态驱动力的变化而恶化？候选基因是否会在清醒时因特定运动或视觉挑战而激活的大脑区域局部增加，以及反弹慢波睡眠得到增强的区域？佩内洛普并不是独自找到奥德修斯的。她的儿子、女仆、诸神和奥德修斯都帮助了她。我们也可能必须进行精心策划的合作努力才能找到我们的奥德修斯。
SLEEP, Vol. 33, No. 9, 2010 1132 Commentary—Veasey deprivation. From this approach, we can conclude that genes for many myelin molecules, membrane and cytoskeleton proteins are suppressed by enforced wakefulness in a corticosterone-dependent fashion. If we wish to answer what processes are disrupted by prolonged sleep restriction, or why do we need to sleep, the adrenals must remain intact, and the approach used by Mackiewicz et al., 13 with several durations of sleep deprivation that provide different levels of homeostatic drive, would be preferable.Let us be as cautious as Penelope in our quest for sleep homeostasis genes. Does a focused proteomics screen (for this mRNA array list) support involvement of these genes in sleep homeostasis? Does Homer1 or any other candidate gene show a dose-dependent response to sleep loss that predicts the homeostatic drive across several strains of mice? Does this gene increase to a larger extent in youth with increased homeostatic drive and does this response deteriorate with aging in parallel with changes in homeostatic drive? Does the candidate gene increase locally in a brain region activated in specific motor or visual challenges across wakefulness and where rebound slow wave sleep is enhanced? Penelope did not find Odysseus by herself; she was helped in her quest by her son, her maid, the gods and Odysseus. We, too, will likely have to put forth a wellplanned collaborative effort to find our Odysseus.