Precise localizations of voltage-gated sodium and potassium channels in neurons.
Precise localizations of voltage-gated sodium and potassium channels in neurons.
复制标题
神经元中电压门控钠通道和钾通道的精确定位。
DOI：
10.1002/dneu.22565
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发表时间：
2018
影响因子：
2.9
通讯作者：
Misonou H.
中科院分区：
文献类型：
--
作者：
Nikaido Masataka;Izumi Saki;Ohnuki Honoka;Takigawa Yuki;Yamasu Kyo;Hatta Kohei;Misonou H.
神经元是非常大和复杂的细胞，它们使用各种离子通道调节多个亚细胞区室中的膜电位。电压门控钠（Nav）和钾（Kv）通道由于其亚型、生物物理性质和定位的多样性而在调节神经元膜兴奋性中至关重要。特别是，在特定的膜隔室中的Nav和Kv通道的特定定位对于实现局部膜兴奋性的精确控制是必不可少的。超分辨率显微镜的最新进展进一步证实了神经元膜中不同离子通道的纳米级定位。这些新的证据线产生了新的问题，关于Nav和Kv通道如何被贩运到特定位置并保持横向扩散。在这篇综述中，目的是总结目前的信息离子通道定位在纳米水平，并讨论我们可以推断的机制。© 2017 Wiley Periodicals，Inc.开发神经生物学78：271-282，2018
Neurons are extremely large and complex cells, and they regulate membrane potentials in multiple subcellular compartments using a variety of ion channels. Voltage‐gated sodium (Nav) and potassium (Kv) channels are crucial in regulating neuronal membrane excitability owing to their diversity in subtypes, biophysical properties, and localizations. In particular, specific localizations of Nav and Kv channels in specific membrane compartments are essential to achieve a precise control of local membrane excitability. Recent advancement in super‐resolution microscopy further substantiated nanoscale localizations of different ion channels in neuronal membranes. New questions arise from these new lines of evidence regarding how Nav and Kv channels are trafficked to a specific location and maintained against lateral diffusion. In this review, the aim is to summarize current information about ion channel localizations at nanoscopic levels and discuss what we can infer regarding the mechanisms. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 271–282, 2018