Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity‐related hepatic insulin resistance
Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity‐related hepatic insulin resistance
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DOI：
10.1002/oby.23361
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发表时间：
2022-02
期刊：
影响因子：
6.9
通讯作者：
Yanping Wang;Jie Xiong;Yanmei Yuan;Chao Peng;Ping Wu;Yibing Wang;Junxi Lu;Yue Yin;
中科院分区：
文献类型：
--
作者：
Yanping Wang;Jie Xiong;Yanmei Yuan;Chao Peng;Ping Wu;Yibing Wang;Junxi Lu;Yue Yin;
受体相互作用丝氨酸/苏氨酸蛋白激酶1（RIP 1）是TNFα介导的炎症、细胞凋亡和坏死性凋亡的关键调节因子，这些炎症、细胞凋亡和坏死性凋亡有助于肥胖相关代谢疾病（如非酒精性脂肪性肝炎）的发生。然而，关于RIP 1如何影响肥胖相关的胰岛素抵抗的机制仍然难以捉摸。
Receptor‐interacting serine/threonine‐protein kinase 1 (RIP1) is a well‐documented key regulator of TNFα‐mediated inflammation, apoptosis, and necroptosis, which contribute to the development of obesity‐related metabolic diseases such as nonalcoholic steatohepatitis. However, the mechanism regarding how RIP1 influences obesity‐related insulin resistance remains elusive.