Infiltration of the brain by pathogens causes Alzheimer's disease
Infiltration of the brain by pathogens causes Alzheimer's disease
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DOI：
10.1016/j.neurobiolaging.2003.12.021
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发表时间：
2004-05-01
影响因子：
4.2
通讯作者：
Balin, B
中科院分区：
文献类型：
--
作者：
Itzhaki, RE;Wozniak, MA;Balin, B
尽管对阿尔茨海默病（AD），特别是淀粉样斑块和神经纤维缠结的研究非常多，但是关于该疾病的原因的信息很少。本文描述的证据表明，当单纯疱疹病毒I型（HSV 1）存在于载脂蛋白E（APOE-ε 4）基因的4型等位基因携带者的大脑中时，它首先是一个强有力的危险因素。间接的支持来自于研究表明APOE在几种不同的已知病原体引起的疾病中的作用。第二个假定的危险因素是细菌，肺炎衣原体。这种病原体已被确定并定位于AD脑中。目前的研究旨在“原理证明”，解决生物体进入CNS，对生物体的神经炎症反应，以及生物体在触发AD病理学中的作用。一种基于感染的动物模型表明，鼻内接种BALB/c小鼠后，C。在感染肺炎后，与AD脑中观察到的一致的淀粉样蛋白斑块/沉积物发展，因此在AD的病因学中涉及这种感染。(C)2004年爱思唯尔公司All rights reserved.
Despite very numerous studies on Alzheimer's disease (AD), especially on amyloid plaques and neurofibrillary tangles, little information has been obtained thus on the causes of the disease. Evidence is described here that implicates firstly herpes simplex virus type I (HSV1) as a strong risk factor when it is present in brain of carriers of the type 4 allele of the gene for apolipoprotein E (APOE-epsilon4). Indirect support comes from studies indicating the role of APOE in several diverse diseases of known pathogen cause.A second putative risk factor is the bacterium, Chlamydia pneumoniae. This pathogen has been identified and localized in AD brain. Current studies aimed at "proof of principle" address the entry of the organism into the CNS, the neuroinflammatory response to the organism, and the role that the organism plays in triggering AD pathology. An infection-based animal model demonstrates that following intranasal inoculation of BALB/c mice with C. pneumoniae, amyloid plaques/deposits consistent with those observed in the AD brain develop, thus implicating this infection in the etiology of AD. (C) 2004 Elsevier Inc. All rights reserved.