REGULATION OF NEURAL INDUCTION BY THE CHD AND BMP-4 ANTAGONISTIC PATTERNING SIGNALS IN XENOPUS
REGULATION OF NEURAL INDUCTION BY THE CHD AND BMP-4 ANTAGONISTIC PATTERNING SIGNALS IN XENOPUS
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DOI：
10.1038/376333a0
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发表时间：
1995-07-27
期刊：
影响因子：
64.8
通讯作者：
DEROBERTIS, EM
中科院分区：
文献类型：
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作者：
SASAI, Y;LU, B;DEROBERTIS, EM
在果蝇中，中枢神经系统（CNS）起源于神经源性外胚层，其数量受位置信息的背腹系统调节，其中两种具有拮抗功能的分泌分子，十肢麻痹（dpp）和短原肠胚形成（sog），起着重要作用（1-4）。dpp的脊椎动物同源物是bmp-4或bmp-2（参考文献5），sog的同源物是chd（4，6，7）（s-chordin）。在非洲爪蟾中，中枢神经系统是由组织者发出的信号诱导的（8），组织者分泌的两种蛋白质，头蛋白（9）和卵泡抑素（10），在动物帽试验中显示出诱导神经组织。在这里，我们报道了Chd，另一种组织特异性分泌因子（6），具有神经化活性，并且这种活性可以被BMP-4拮抗。抑制存在于动物cap（1）1中的内源性Bmp-4的功能也导致神经分化。我们认为，保守的分子机制，涉及chd/sog和BMP-4/DPP基因产物的模式外胚层在非洲爪蟾和果蝇。
IN Drosophila the amount of neurogenic ectoderm, from which the central nervous system (CNS) derives, is regulated by a dorsal-ventral system of positional information in which two secreted molecules of antagonistic functions, decapentaplegic (dpp) and short-gastrulation (sog), play fundamental roles(1-4). The vertebrate homologue of dpp is either bmp-4 or bmp-2 (ref. 5), and the homologue of sog is chd(4,6,7) (s-chordin). In Xenopus the CNS is induced by signals emanating from the organizer(8), and two proteins secreted by the organizer, noggin(9) and follistatin(10), have been shown to induce neural tissue in animal-cap assays. Here we report that Chd, another organizer-specific secreted factor(6), has neuralizing activity and that this activity can be antagonized by Bmp-4. Inhibition of the function of the endogenous Bmp-4 present in the animal cap(1)1 also leads to neural differentiation. We suggest that conserved molecular mechanisms involving chd/sog and bmp-4/dpp gene products pattern the ectoderm in Xenopus and in Drosophila.