Decreasing podocyte number during human kidney intrauterine development
Decreasing podocyte number during human kidney intrauterine development
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DOI：
10.1152/ajprenal.00165.2014
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发表时间：
2014-11-01
影响因子：
4.2
通讯作者：
Faa, G.
中科院分区：
文献类型：
--
作者：
Crobe, A.;Desogus, M.;Faa, G.
出生时肾元数量对长期肾脏健康具有重要的临床意义。近年来，足细胞耗竭假说已成为肾脏病理学的一个重要概念。本研究旨在验证人足细胞数量是否在子宫内发生显著变化。为此，我们对62名胎龄在20 ~ 41周的受试者进行了检查。肾切片用苏木精和伊红染色，并在x400倍放大下进行数字扫描。受试者再分为胎龄为25周和37周的胎儿，n = 18)。胎儿、早产儿和足月新生儿的平均足细胞数分别为1,908 +/- 645、1,394 +/- 498和1,126 +/- 256。胎龄对足细胞数量有显著主效应（P = 0.0051），足月新生儿足细胞数量显著低于胎儿足细胞数量（P < 0.01）。组内变异性也被观察到。我们推测足细胞数量的变化可能与宫内生活中发生的药物和母亲饮食等因素有关。总之，本研究首次显示妊娠期足细胞数量呈下降趋势。
Nephron number at birth has relevant clinical importance with implications for long-term renal health. In recent years, the podocyte depletion hypothesis has emerged as an important concept in kidney pathology. This study was aimed at verifying whether human podocyte number changes significantly during intrauterine life. To this end, 62 subjects with gestational ages ranging from 20 to 41 wk were examined. Kidney sections were stained with hematoxylin and eosin and digitally scanned at x400 magnification. Subjects were subdivided into fetuses (gestational age = 25 and = 37 wk, n = 18). The average podocyte number of 1,908 +/- 645, 1,394 +/- 498, and 1,126 +/- 256 was, respectively, observed in fetuses, preterms, and full-term newborns. A significant main effect (P = 0.0051) of gestational age on podocyte number was observed with a significantly lower number in full-term newborns than in fetuses (P < 0.01). Intragroup variability was also observed. We speculate that variations in podocyte number could be correlated with factors such as drugs and maternal diet occurring during intrauterine life. In conclusion, this study shows, for the first time, a decreasing trend in podocyte number during gestation.