Relationship between bilirubin and C-reactive protein
Relationship between bilirubin and C-reactive protein
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DOI：
10.1515/cclm.2011.662
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发表时间：
2011-11-01
影响因子：
6.8
通讯作者：
Kim, Sang-Hwan
中科院分区：
文献类型：
--
作者：
Hwang, Hee-Jin;Lee, Sang-Woo;Kim, Sang-Hwan
背景：流行病学研究表明，血清总胆红素与冠状动脉疾病风险增加呈负相关。然而，关于胆红素与慢性血管炎症标志物c反应蛋白（C-reactive protein， CRP）之间关系的研究数量有限。方法：本横断面研究包括2009年1月至2009年12月到健康促进中心进行常规健康检查的2307名韩国成年人。结果：CRP水平随总胆红素升高呈下降趋势。调整年龄、体重指数、高血压、糖尿病、高胆固醇血症、心血管疾病、服用阿司匹林、吸烟、饮酒、经常运动、总胆红素或直接胆红素后，CRP与总胆红素和直接胆红素均呈负相关。结论：本研究发现，在表面健康的韩国成年人中，两种胆红素（总胆红素和直接胆红素）的升高与血清CRP水平低有关。据推测，血清CRP水平低可能与胆红素代谢的抗氧化和抗炎作用有关。
Background: Epidemiologic studies have shown that serum total bilirubin is inversely related to an increased risk of coronary artery disease. However, the number of studies which have focused on the relationship between bilirubin and C-reactive protein (CRP), which is a marker reflecting chronic vascular inflammation, are limited.Method: This cross-sectional study consisted of 2307 Korean adults who visited the Center for Health Promotion for a routine health check-up from January 2009 to December 2009.Result: CRP level showed a declining tendency as total bilirubin increased according to total bilirubin quartiles. Negative relations of CRP with both total and direct bilirubin were found after adjustment of age, body mass index, hypertension, diabetes, hypercholesterolemia, cardiovascular disease, taking aspirin, smoking, alcohol drinking and regular exercise and total bilirubin or direct bilirubin.Conclusions: This study found that elevation of the two types of bilirubin (total and direct) have a relationship with a low serum CRP level among apparently healthy Korean adults. It is hypothesized that a low serum CRP level may be due to the antioxidant and anti-inflammatory effects of bilirubin metabolism.