The Dopamine D4 Receptor Gene (DRD4) Moderates Cultural Difference in Independent Versus Interdependent Social Orientation
The Dopamine D4 Receptor Gene (DRD4) Moderates Cultural Difference in Independent Versus Interdependent Social Orientation
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DOI：
10.1177/0956797614528338
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发表时间：
2014-06-01
影响因子：
8.2
通讯作者：
Liberzon, Israel
中科院分区：
文献类型：
--
作者：
Kitayama, Shinobu;King, Anthony;Liberzon, Israel
先前的研究表明，文化群体在独立与相互依赖的社会取向的总体维度上有所不同，欧洲裔美国人比亚洲人更独立，或更不相互依赖。根据最近的证据表明多巴胺 D4 受体基因 (DRD4) 在调节文化学习中发挥作用，我们预测与非携带者相比，与多巴胺信号传导增强（7 或 2 重复等位基因）相关的 DRD4 多态性携带者将表现出更高水平的文化主导社会取向。欧洲裔美国人和亚裔出生的亚洲人（总计 N = 398）在多个维度上报告了他们的社会取向。他们还对 DRD4 进行了基因分型。与早期的研究一样，欧洲裔美国人更加独立，而亚裔出生的亚洲人则更加相互依赖。对于 7 或 2 重复等位基因的携带者来说，这种文化差异比非携带者更为明显。事实上，非携带者之间没有明显的文化差异。讨论了基因和文化潜在共同进化的影响。
Prior research suggests that cultural groups vary on an overarching dimension of independent versus interdependent social orientation, with European Americans being more independent, or less interdependent, than Asians. Drawing on recent evidence suggesting that the dopamine D4 receptor gene (DRD4) plays a role in modulating cultural learning, we predicted that carriers of DRD4 polymorphisms linked to increased dopamine signaling (7- or 2-repeat alleles) would show higher levels of culturally dominant social orientations, compared with noncarriers. European Americans and Asian-born Asians (total N = 398) reported their social orientation on multiple scales. They were also genotyped for DRD4. As in earlier work, European Americans were more independent, and Asian- born Asians more interdependent. This cultural difference was significantly more pronounced for carriers of the 7- or 2-repeat alleles than for noncarriers. Indeed, no cultural difference was apparent among the noncarriers. Implications for potential coevolution of genes and culture are discussed.