Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study.
Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study.
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DOI：
10.5498/wjp.v6.i4.419
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发表时间：
2016-12-22
影响因子：
3.1
通讯作者：
Preisig M
中科院分区：
文献类型：
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作者：
Ajdacic-Gross V;Aleksandrowicz A;Rodgers S;Mutsch M;Tesic A;Müller M;Kawohl W;Rössler W;Seifritz E;Castelao E;Strippoli MF;Vandeleur C;von Känel R;Paolicelli R;Landolt MA;Witthauer C;Lieb R;Preisig M
在调整其他危险因素的同时，检查精神障碍与感染性、特应性、炎症性疾病之间的关系。我们使用了来自PsyCoLaus的数据，这是一项大型瑞士人群队列研究（n = 3720;年龄范围35-66）。精神障碍的终生诊断分为以下几类：神经发育、焦虑（早发和晚发）、情绪和物质障碍。他们在感染性、特应性和其他炎症性疾病方面进行了回归，调整了性别、教育水平、家庭聚集、童年逆境和童年创伤经历。多变量logistic回归应用于每组疾病。在补充分析中，通过嵌套效应引入了与性别的相互作用。与感染性，特应性和其他慢性炎症性疾病的关联是观察到的，与儿童期逆境和家庭聚集的一致影响，以及创伤在各组精神障碍中的不太一致的影响。链球菌感染与神经发育障碍有关（男性），麻疹/腮腺炎/风疹感染与早期和晚期焦虑症有关（女性）。胃炎症性疾病对情绪障碍（两种性别）和早期障碍（男性）都有影响。同样，肠易激综合征在女性情绪障碍中以性别特异性方式突出，而且与早期和晚期焦虑症相关。特应性疾病与晚期焦虑症相关。痤疮（与男性情绪障碍相关）和银屑病（与男性早期焦虑症和女性情绪障碍相关）贡献了性别特异性结果。尿路感染与情绪障碍有关，此外，在性别特异性的方式与晚期焦虑症（男性），神经发育和早期焦虑症（女性）。传染性、特应性和炎症性疾病是所有精神障碍群体的重要危险因素。群丛的两性异形是明显的。
To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors. We used data from PsyCoLaus, a large Swiss Population Cohort Study (n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety (early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders (men), and measles/mumps/rubella-infections with early and late anxiety disorders (women). Gastric inflammatory diseases took effect in mood disorders (both sexes) and in early disorders (men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne (associations with mood disorders in men) and psoriasis (associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders (men), and neurodevelopmental and early anxiety disorders (women). Infectious, atopic and inflammatory diseases are important risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced.