Metastatic tumor cell interactions with endothelium, basement membrane and tissue
Metastatic tumor cell interactions with endothelium, basement membrane and tissue
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DOI：
10.1016/0955-0674(89)90073-2
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发表时间：
1989-10-01
影响因子：
7.5
通讯作者：
Nicolson, G. L.
中科院分区：
文献类型：
--
作者：
Nicolson, G. L.
肿瘤通过一系列复杂的连续步骤进行转移，包括原发部位恶性细胞的生长和侵袭，渗透到淋巴管、血液循环和体腔，运输到远处部位，在这些部位植入，以及侵袭和生长（图1）。通常，转移可能发生在选择性的继发部位，由于机械方面的考虑或循环或淋巴模式，这是意想不到的[11。这些发现引起了研究人员的兴趣，并刺激了对恶性细胞扩散到特定部位的分子事件的研究。
Tumors metastasize by way of a complex series of sequential steps involving the growth and invasion of malignant cells at primary sites, their penetration into lymphatits, blood circulation and body cavities, transport to distant sites, implantation at these sites, and invasion and growth (Fig. 1). Often metastasis can occur to selective secondary sites that would be unexpected on the basis of mechanical considerations or circulatory or lymphatic patterns [11. Such findings have intrigued researchers and have stimulated research into the molecular events underlying the spread of malignant cells to particular sites.