Building a research consortium of large health systems: the Cancer Research Network.
Building a research consortium of large health systems: the Cancer Research Network.
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DOI：
10.1093/jncimonographs/lgi032
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Vogt, Thomas M
中科院分区：
文献类型：
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作者：
Wagner, Edward H;Greene, Sarah M;Vogt, Thomas M
关于预防癌症，护理和结果的关键问题越来越多地需要涉及大量患者人群及其护理组织的研究。癌症研究网络（CRN）包括由国家癌症研究所（NCI）资助的11个综合卫生系统，用于进行协作癌症研究。本文介绍了构建大型卫生系统生产财团的挑战，并探讨了CRN的反应。 CRN最初是通过1999年的NCI合作协议资助的，此后已获得第二份4年赠款。领导和政策制定是通过指导委员会，小组委员会和外部咨询委员会提供的。 CRN包括科学和数据资源核心支持的积分和附属研究项目。 CRN的三个特征加剧了财团研究的一般挑战：1）其成员是大型卫生系统，对有关参与者，提供者和组织的数据机密性的合理担忧； 2）CRN研究项目通常会产生有关护理质量的高度敏感数据；因此3）每个参与组织都希望在CRN方向上发表强烈的声音。迄今为止，CRN的经验证实，具有内部研究能力的卫生系统财团可以解决一系列重要的癌症研究问题，这些问题在其他场所很难研究。探索了财团研究的优势和挑战，并提出了多系统人口实验室的发展，执行和管理的建议。
Critical questions about cancer prevention, care, and outcomes increasingly require research involving large patient populations and their care delivery organizations. The Cancer Research Network (CRN) includes 11 integrated health systems funded by the National Cancer Institute (NCI) to conduct collaborative cancer research. This article describes the challenges of constructing a productive consortium of large health systems, and explores the CRN's responses. The CRN was initially funded through an NCI cooperative agreement in 1999 and has since received a second 4-year grant. Leadership and policy development are provided through a steering committee, subcommittees, and an external advisory committee. The CRN includes integral and affiliated research projects supported by a Scientific and Data Resources Core. Three characteristics of the CRN intensified the general challenges of consortium research: 1) its members are large health systems with legitimate concerns about confidentiality of data about enrollees, providers, and the organization; 2) CRN research projects often generate highly sensitive data about quality of care; and therefore 3) each participating organization wants a strong voice in CRN direction. CRN experience to date confirms that a consortium of health systems with internal research capacity can address a range of important cancer research questions that would be difficult to study in other venues. The advantages and challenges of consortium research are explored, with suggestions for the development, execution, and management of multisystem population laboratories.