Infrared thermography in the detection of brown adipose tissue in humans.
Infrared thermography in the detection of brown adipose tissue in humans.
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DOI：
10.14814/phy2.12167
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发表时间：
2014-11-01
影响因子：
2.5
通讯作者：
Ho KK
中科院分区：
文献类型：
--
作者：
Jang C;Jalapu S;Thuzar M;Law PW;Jeavons S;Barclay JL;Ho KK
使用18F-FDG的PET-CT用于检测人体中的棕色脂肪组织（BAT）。由于PET-CT成像的辐射和成本，需要替代方法。目的是评价红外热成像（IRT）检测人体BAT的准确性，以PET ‐ CT成像为基准。17名受试者共接受了29次PET ‐ CT扫描，其中12名受试者在19 ° C下接受2小时冷刺激后接受了两次研究，同时在冷刺激前后测量锁骨上窝（SCV）和外侧上胸部（对照）的皮肤温度。在29次扫描中，20次冷刺激后BAT阳性。冷却前和冷却期间，BAT阳性组的平均左SCV温度往往较高。它显著高于（P = 0.04）对照区的温度，在BAT阳性组（-1.2 ± 0.3 ° C，P = 0.002）但在阴性组（-0.2 ± 0.4 ° C）中，对照区的温度在冷却过程中显著下降。BAT阳性组在冷却过程中左SCV和胸部之间的温差（Δ temp）增加（1.2 ± 0.2至2.0 ± 0.3 ° C，P <0.002），但在阴性组中没有增加（0.6 ± 0.1至0.7 ± 0.1 ° C）。0.9 ° C的Δ温度赋予SCV BAT的阳性预测值为85%，上级于SCV温度。右边的结果也类似。总之，BAT阳性受试者的Δ temp显著且一致地更高。在2 h冷却后通过IRT量化的Δ温度显示出作为研究SCV BAT功能的无创方便技术的前景。使用红外热成像（IRT），我们观察到存在棕色脂肪组织（BAT）的锁骨上窝（SCV）的皮肤温度高于对照BAT阴性胸部区域的皮肤温度。在BAT受试者中，这种温差更大，并且以PET/CT成像为基准，BAT的阳性预测值为85%。IRT显示出作为检测人类BAT功能的工具的前景。
PET‐CT using 18F‐FDG is employed for detecting brown adipose tissue (BAT) in humans. Alternative methods are needed because of the radiation and cost of PET‐CT imaging. The aim was to evaluate the accuracy of infrared thermography (IRT) in detecting human BAT benchmarked to PET‐CT imaging. Seventeen individuals underwent a total of 29 PET‐CT scans, 12 of whom were studied twice, after 2 h of cold stimulation at 19°C, in parallel with measurement of skin temperatures overlying the supraclavicular (SCV) fossa and the lateral upper chest (control), before and after cold stimulation. Of the 29 scans, 20 were BAT positive after cold stimulation. The mean left SCV temperature tended to be higher in the BAT‐positive group before and during cooling. It was significantly higher (P =0.04) than the temperature of the control area, which fell significantly during cooling in the BAT‐positive (−1.2 ± 0.3°C, P =0.002) but not in the negative (−0.2 ± 0.4°C) group. The temperature difference (Δtemp) between left SCV and chest increased during cooling in the BAT‐positive (1.2 ± 0.2 to 2.0 ± 0.3°C, P <0.002) but not in the negative group (0.6 ± 0.1 to 0.7 ± 0.1°C). A Δtemp of 0.9°C conferred a positive predictive value of 85% for SCV BAT, superior to that of SCV temperature. The findings were similar on the right. In conclusion, the Δtemp is significantly and consistently greater in BAT‐positive subjects. The Δtemp quantified by IRT after 2‐h cooling shows promise as a noninvasive convenient technique for studying SCV BAT function. Using infrared thermography (IRT), we observed the skin temperature of the supraclavicular fossa (SCV) where brown adipose tissue (BAT) is present, to be higher than that of a control BAT‐negative chest area. This temperature difference was greater in subjects with BAT and conferred a positive predictive value of 85% for BAT benchmarked to PET/CT imaging. IRT shows promise as a tool for detecting BAT function in humans.