Reduced left hemispheric white matter volume in twins with bipolar I disorder
Reduced left hemispheric white matter volume in twins with bipolar I disorder
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DOI：
10.1016/s0006-3223(03)00373-1
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发表时间：
2003-11-01
影响因子：
10.6
通讯作者：
Lönnqvist, J
中科院分区：
文献类型：
--
作者：
Kieseppä, T;van Erp, TGM;Lönnqvist, J
背景：尽管 I 型双相情感障碍 (BPI) 的遗传力很高，但针对双相情感障碍患者兄弟姐妹的磁共振成像 (MRI) 研究却很少。我们对全国范围内患有 BPI 的双胞胎样本以及其同卵双胞胎和人口统计平衡的对照双胞胎样本进行了 MRI 脑部扫描，以检测与该疾病和增加的遗传风险相关的任何结构改变。方法：使用国家医院出院登记处、国家人口登记处和芬兰双胞胎队列来识别双相双胞胎。对 24 名 BPI 双胞胎、15 名健康双胞胎和 27 名对照双胞胎受试者进行了结构化诊断访谈和 MRI 扫描。结果：患者和双胞胎的左半球白质体积显着减少。与对照双胞胎受试者相比，患者的差异为-16.1 cm(3)（95%置信区间[CI]-26.6，-5.6），同卵双胞胎的差异为-11.3 cm（3）（95% CI -22.1，-0.4）。在患者或双胞胎中未发现灰质减少。结论：对患有 BPI 的双胞胎、其双胞胎和适当的对照双胞胎受试者进行的首次大规模 MRI 研究结果表明，BPI 中左半球白质的变化可能反映了易患该疾病的遗传因素。 (C) 2003 年生物精神病学协会。
Background: Although the heritability of bipolar I disorder (BPI) is high, few magnetic resonance imaging (MRI) studies of siblings of bipolar patients exist. We performed MRI brain scans on a nationwide sample of twins with BPI, as well as on their co-twins and a demographically balanced sample of control twin subjects, to detect any structural alterations related to the disorder and to the increased genetic risk.Methods: The National Hospital Discharge Register, National Population Register, and Finnish Twin Cohorts were used to identify bipolar twins. Structured diagnostic interviews and MRI scans were obtained for 24 twins with BPI, 15 healthy co-twins, and 27 control twin subjects.Results: Patients and co-twins showed a significant decrease in left hemispheric white matter volume. The disparity in patients was -16.1 cm(3) (95% confidence interval [CI] -26.6, -5.6) and in co-twins -11.3 cm (3) (95% CI -22.1, -0.4) compared with control twin subjects. No gray matter decrease was seen in patients or co-twins.Conclusions: The results of this first large-scale MRI study of twins with BPI, their co-twins, and appropriate control twin subjects, suggest that alterations of the left hemisphere white matter in BPI may reflect genetic factors predisposing to the disorder. (C) 2003 Society of Biological Psychiatry.