Distension of the urinary bladder in rats fed saccharin containing diet.

Distension of the urinary bladder in rats fed saccharin containing diet.
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喂食含糖精饮食的大鼠膀胱扩张。

DOI:
10.1016/0304-3835(83)90118-0
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发表时间:
1983
期刊:
影响因子:
9.7
通讯作者:
J. Sims
J. Sims
中科院分区:
医学1区
文献类型:
--
作者:
A. Renwick;J. Sims

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给大鼠随意饲喂含7.5%糖精的日粮1个月后,大鼠日摄水量和总尿量增加。更大的尿量与排尿频率和平均排尿量的增加有关。饲喂糖精的大鼠,每24 h超过1.0 ml的总排尿次数增加了3倍,检测到的最大排尿量几乎增加了一倍。这些结果表明,在前两代癌症生物测定中使用的高饮食水平的短期管理会产生膀胱的功能变化,该器官显示肿瘤发生率增加。
The administration of a diet containing 7.5% saccharin ad libitum to rats for 1 month caused an increase in the daily water intake and total urine volume. The greater urine volume was associated with an increase in both the frequency of urination and the average volume per urination. In saccharin-fed rats the total number of urinations per 24 h which exceeded 1.0 ml was increased 3-fold whilst the maximum urination volume detected was almost doubled. These results show that the short-term administration of the high dietary levels used in previous 2-generation cancer bioassays produces functional changes in the urinary bladder, the organ showing an increased incidence of tumours.
按分子量分级的大鼠尿液对膀胱癌发生的影响。
DOI: --
发表时间: 1982
期刊: Cancer research
影响因子: 11.2
作者:
Babaya,K;Miyata,Y;Chmiel,JS;Oyasu,R
通讯作者: Oyasu,R
DOI: --
发表时间: 1981
期刊: Cancer research
影响因子: 11.2
作者:
Oyasu,R;Hirao,Y;Izumi,K
通讯作者: Izumi,K