MR imaging of the stomach: potential use for mangafodipir trisodium--a study in swine.
MR imaging of the stomach: potential use for mangafodipir trisodium--a study in swine.
复制标题
胃 MR 成像：锰福地吡三钠的潜在用途——一项猪研究。
DOI：
10.1148/radiol.2321030876
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Rofsky,NeilM
中科院分区：
文献类型：
--
作者：
Zuo,ChunS;Seoane,PeterR;Hu,Jiani;Harnish,PhilipP;Rofsky,NeilM
目的：评价锰福地吡三钠作为胃磁共振（MR）成像的潜在造影剂。材料与方法：将锰福地吡三钠以每公斤体重5μmol的剂量静脉注射给三头猪。为了进行比较，将钆喷酸二葡胺以每公斤体重 0.1 mmol 的剂量注射到其他三头猪中。在给予造影剂之前和之后大约 10、15、20、25、30 和 40 分钟，以 1.5 T 采集所有六头猪的 T1 加权三维 MR 图像。提取的胃标本在 3.0 T 下成像。对体内和离体图像进行目视和定量评估，以评估胃的对比度增强情况，并评估体内图像是否存在十二指肠反流。结果：锰福地吡三钠对胃内表面产生了持久和选择性的增强，与钆喷酯所见的更普遍的增强形成鲜明对比 二甲葡胺和十二指肠反流不能解释这种选择性增强。离体图像证实锰福地吡三钠对胃壁的 T1 增强仅限于内表面。钆喷酸二甲葡胺不会对胃内表面产生选择性增强。结论：锰福地吡三钠优先增强猪 MR 图像上的胃内表面，因此，可能有潜力用作人类胃 MR 成像中的造影剂。© RSNA，2004
PURPOSE:To evaluate mangafodipir trisodium as a potential contrast agent at magnetic resonance (MR) imaging of the stomach.MATERIALS AND METHODS:Mangafodipir trisodium was injected intravenously into three swine at a dose of 5 μmol per kilogram of body weight. For comparison, gadopentetate dimeglumine was injected into three other swine at a dose of 0.1 mmol per kilogram of body weight. T1-weighted three-dimensional MR images were acquired in all six swine at 1.5 T before and approximately 10, 15, 20, 25, 30, and 40 minutes after contrast material administration. Extracted stomach specimens were imaged at 3.0 T. In vivo and ex vivo images were evaluated visually and quantitatively for contrast enhancement of the stomach, and in vivo images were evaluated for the presence of reflux from the duodenum.RESULTS:Mangafodipir trisodium produced prolonged and selective enhancement of the inner surface of the stomach, in contrast to the more general enhancement seen with gadopentetate dimeglumine, and reflux from the duodenum could not account for this selective enhancement. Ex vivo images confirmed that T1 enhancement in the stomach wall with mangafodipir trisodium was limited to the inner surface. Gadopentetate dimeglumine did not produce selective enhancement of the inner surface of the stomach.CONCLUSION:Mangafodipir trisodium preferentially enhances the inner surface of the stomach on MR images acquired in swine and, therefore, may have potential for use as a contrast agent at MR imaging of the human stomach.© RSNA, 2004