PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
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DOI：
10.1016/j.bbalip.2009.04.002
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发表时间：
2009-06
影响因子：
4.8
通讯作者：
Welte, Michael A.
中科院分区：
文献类型：
--
作者：
Bickel, Perry E.;Tansey, John T.;Welte, Michael A.
PAT家族的脂滴蛋白在哺乳动物中包括5个成员：围脂蛋白、脂肪分化相关蛋白（ADRP）、47千道尔顿的尾相互作用蛋白（TIP 47）、S3-12和OXPAT。这个家族的成员也存在于进化上遥远的生物体中，包括昆虫，黏菌和真菌。所有PAT蛋白都具有序列相似性和结合细胞内脂滴的能力，无论是组成性的还是响应于代谢刺激，如增加的脂质流入或流出脂滴。位于脂滴表面，PAT蛋白管理其他蛋白质（脂肪酶）进入脂滴核心内的脂质酯，并可与脂滴生物发生重要的细胞机制相互作用。哺乳动物PAT蛋白的最佳特征基因周脂蛋白的遗传变异与代谢表型相关，包括2型糖尿病和肥胖症。在这篇综述中，我们讨论了PAT蛋白如何调节哺乳动物和模式生物的细胞脂质代谢。
The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose differentiation-related protein (ADRP), tail-interacting protein of 47 kiloDaltons (TIP47), S3-12, and OXPAT. Members of this family are also present in evolutionarily distant organisms, including insects, slime molds and fungi. All PAT proteins share sequence similarity and the ability to bind intracellular lipid droplets, either constitutively or in response to metabolic stimuli, such as increased lipid flux into or out of lipid droplets. Positioned at the lipid droplet surface, PAT proteins manage access of other proteins (lipases) to the lipid esters within the lipid droplet core and can interact with cellular machinery important for lipid droplet biogenesis. Genetic variations in the gene for the best characterized of the mammalian PAT proteins, perilipin, have been associated with metabolic phenotypes, including type 2 diabetes mellitus and obesity. In this review, we discuss how the PAT proteins regulate cellular lipid metabolism both in mammals and in model organisms.
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