The first reagent-controlled asymmetric halolactonizations. Dihydroquinidine-halogen complexes as chiral sources of positive halogen ion
The first reagent-controlled asymmetric halolactonizations. Dihydroquinidine-halogen complexes as chiral sources of positive halogen ion
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DOI：
10.1139/cjc-76-9-1233
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发表时间：
1998-09-01
影响因子：
1.1
通讯作者：
Trupp, RJ
中科院分区：
文献类型：
--
作者：
Grossman, RB;Trupp, RJ
描述了第一个试剂控制的不对称卤代内酯反应。I+与O-酰基和O-芳基二氢奎尼丁的络合物被用来促进前手性伽马、三角洲不饱和羧酸的不对称卤代内酯反应，具有较低的但可测量和可重现的对映选择性。文中描述了影响等效应系数的实验因素。
The first reagent-controlled asymmetric halolactonizations are described. Complexes of I+ with O-acyl- and O-aryldihydroquinidines are used to promote the asymmetric halolactonization of prochiral gamma,delta-unsaturated carboxylic acids with low but measurable and reproducible enantioselectivity. Experimental factors affecting the ee's are described.