Synthesis of nitrogen and sulfur analogues of the seco-CI alkylating agent
Synthesis of nitrogen and sulfur analogues of the seco-CI alkylating agent
复制标题
Seco-CI烷基化剂的氮和硫类似物的合成
DOI：
--
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
W. Denny
中科院分区：
文献类型：
--
作者：
M. Tercel;W. Denny
报道了两种以氯硝基苯甲酸异构体为原料合成氨基开环-Cl（Cl = 1a，2，3，5-四氢-1H-环丙[1，2-c]吲哚-5-酮）烷基化试剂的方法。还描述了这些化合物的进一步反应，包括重氮化为苯酚和苯硫酚衍生物，以及与前药形式的制备相关的烷基化和酰化反应。
Two complementary syntheses of amino seco-CI (CI = 1a,2,3,5-tetrahydro-1H-cycloprop[1,2-c]indol-5-one) alkylating agents starting from isomeric chloronitrobenzoic acids are reported. Further reactions of these compounds, including diazotisation to phenol and thiophenol derivatives, and alkylation and acylation reactions relevant to the preparation of pro-drug forms are also described.