Enveloped artificial viral capsids self-assembled from anionic β-annulus peptide and cationic lipid bilayer
Enveloped artificial viral capsids self-assembled from anionic β-annulus peptide and cationic lipid bilayer
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DOI：
10.1039/d0cc02622k
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发表时间：
2020-07-04
影响因子：
4.9
通讯作者：
Matsuura, Kazunori
中科院分区：
文献类型：
--
作者：
Furukawa, Hiroto;Inaba, Hiroshi;Matsuura, Kazunori
以β-环-EE肽为模板，自组装成阴离子型人工病毒衣壳，然后与含有脂质双层的阳离子脂质通过静电相互作用形成有包膜的人工病毒衣壳。包膜的人工病毒衣壳的临界聚集浓度显著低于未复合的人工病毒衣壳的临界聚集浓度，表明脂质双层稳定了衣壳结构。
Anionic artificial viral capsids were self-assembled from beta-annulus-EE peptide, then complexed with lipid-bilayer-containing cationic lipids via electrostatic interaction to form enveloped artificial viral capsids. The critical aggregation concentration of the enveloped artificial viral capsid was significantly lower than that of the uncomplexed artificial viral capsid, indicating that the lipid bilayer stabilised the capsid structure.