Cerebrospinal fluid levels of glial marker YKL-40 strongly associated with axonal injury in HIV infection
Cerebrospinal fluid levels of glial marker YKL-40 strongly associated with axonal injury in HIV infection
复制标题
脑脊液中胶质标志物YKL-40水平与HIV感染中的轴突损伤密切相关
DOI：
10.1186/s12974-019-1404-9
复制
发表时间：
2019-01-24
影响因子：
9.3
通讯作者：
Gisslen, Magnus
中科院分区：
文献类型：
--
作者：
Hermansson, Linn;Yilmaz, Aylin;Gisslen, Magnus
BackgroundHIV-1 infects the central nervous system (CNS) shortly after transmission. This leads to a chronic intrathecal immune activation. YKL-40, a biomarker that mainly reflects activation of astroglial cells, has not been thoroughly investigated in relation to HIV. The objective of our study was to characterize cerebrospinal fluid (CSF) YKL-40 in chronic HIV infection, with and without antiretroviral treatment (ART).MethodsYKL-40, neopterin, and the axonal marker neurofilament light protein (NFL) were analyzed with ELISA in archived CSF samples from 120 HIV-infected individuals (85 untreated neuroasymptomatic patients, 7 with HIV-associated dementia, and 28 on effective ART) and 39 HIV-negative controls.ResultsCSF YKL-40 was significantly higher in patients with HIV-associated dementia compared to all other groups. It was also higher in untreated neuroasymptomatic individuals with CD4 cell count
