Contributions of total and regional fat mass to risk for cardiovascular disease in older women
Contributions of total and regional fat mass to risk for cardiovascular disease in older women
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DOI：
10.1152/ajpendo.00467.2001
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发表时间：
2002-05-01
影响因子：
5.1
通讯作者：
Kohrt, WM
中科院分区：
文献类型：
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作者：
Van Pelt, RE;Evans, EM;Kohrt, WM
本研究的目的是确定通过双能x线吸收仪（DEXA）测量的躯干脂肪量是否可以预测绝经后妇女的胰岛素抵抗和血脂异常，独立于手臂和腿部脂肪量。用DEXA测量166名健康绝经后妇女（66±4岁）的总体和局部身体组成。评估胰岛素抵抗和血脂异常的四个主要标志物：1)口服葡萄糖耐量试验（OGTT）的胰岛素应答曲线下面积（INSAUC）， 2) OGTT葡萄糖和胰岛素面积的乘积（INSAUC x GLU（AUC)）， 3)血清甘油三酯（TG）， 4）高密度脂蛋白(HDL)-胆固醇。躯干脂肪量是每个主要因变量的最强独立预测因子。在多元回归模型中，躯干脂肪量与不利的INSAUC、INSAUC x GLU（AUC）、TG和HDL-C水平相关，而腿部脂肪量与这些变量均有利相关。因此，躯干脂肪是绝经后妇女胰岛素抵抗和血脂异常的一个强有力的独立预测因子，而腿部脂肪似乎对代谢功能障碍具有保护作用。
The aim of this study was to determine whether trunk fat mass, measured by dual-energy X-ray absorptiometry (DEXA), is predictive of insulin resistance and dyslipidemia, independently of arm and leg fat mass, in postmenopausal women. Total and regional body composition was measured by DEXA in 166 healthy, postmenopausal women (66 +/- 4 yr). Four primary markers of insulin resistance and dyslipidemia were assessed: 1) area under the curve for the insulin (INSAUC) response to an oral glucose tolerance test (OGTT), 2) product of the OGTT glucose and insulin areas (INSAUC x GLU(AUC)), 3) serum triglycerides (TG), and 4) high-density lipoprotein (HDL)-cholesterol. Trunk fat mass was the strongest independent predictor of each of the primary dependent variables. In multivariate regression models, trunk fat mass was associated with unfavorable levels of INSAUC, INSAUC x GLU(AUC), TG, and HDL-C, whereas leg fat mass was favorably associated with each of these variables. Thus trunk fat is a strong independent predictor of insulin resistance and dyslipidemia in postmenopausal women, whereas leg fat appears to confer protective effects against metabolic dysfunction.