Visual discrimination learning in zebrafish (Danio rerio)
Visual discrimination learning in zebrafish (Danio rerio)
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DOI：
10.1016/j.beproc.2005.03.001
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发表时间：
2005-08-31
影响因子：
1.3
通讯作者：
Escudero, H
中科院分区：
文献类型：
--
作者：
Colwill, RM;Raymond, MP;Escudero, H
三个实验证明了斑马鱼（Danio rerio）的视觉辨别学习。在每个实验中，斑马鱼在T型迷宫的两个视觉上不同的臂之间进行选择。选择一种刺激物之后总是有食物奖励，但选择另一种刺激物则没有奖励。在实验I（绿色和紫色）和实验2（红色和蓝色）中使用了围绕T-迷宫臂装配的不同颜色的套筒。实验3中使用的刺激物是内衬有水平或垂直黑色条纹的白色袖子。在所有三个实验中，斑马鱼都获得了对导致食物奖励的刺激的显著偏好。实验1和2还表明，斑马鱼可以学习逆转的歧视。最后，在实验2中的反转训练后和实验1和3中的初始辨别训练后，检查了停止食物奖励的效果。非强化导致实验2和3中的正确反应独立的刺激身份的减少，但在实验1中的响应的不对称模式。在所有三个实验中，选择反应的中位潜伏期在采集过程中下降;在灭绝过程中，中位反应时间在实验I中没有变化，在实验2中仅略有增加，但在实验3中显示出大幅增加。这些结果的影响，斑马鱼作为一个模型系统的学习和记忆的遗传研究进行了讨论。(c)2005 Elsevier B. V.保留所有权利。
Three experiments demonstrated visual discrimination learning in zebrafish (Danio rerio). In each experiment, zebrafish were given a choice between two visually distinct arms of a T-maze. Choice of one stimulus was always followed by a food reward, but choice of the other stimulus was not rewarded. Different colored sleeves fitted around the arms of the T-maze were used in Experiments I (green and purple) and 2 (red and blue). The stimuli used in Experiment 3 were white sleeves lined with horizontal or vertical black stripes. In all three experiments, zebrafish acquired a significant preference for the stimulus that led to a food reward. Experiments I and 2 also showed that zebrafish could learn a reversal of the discrimination. Finally, the effect of discontinuing food rewards was examined after reversal training in Experiment 2 and after initial discrimination training in Experiments 1 and 3. Non-reinforcement led to a decrease in correct responding in Experiments 2 and 3 independent of stimulus identity, but to an asymmetrical pattern of responding in Experiment 1. The median latency to make a choice response decreased over the course of acquisition in all three experiments; during extinction, median response times did not change at all in Experiment I and increased only very slightly in Experiment 2, but showed a substantial increase in Experiment 3. The implications of these results for the zebrafish as a model system for genetic studies of learning and memory are discussed. (c) 2005 Elsevier B.V. All rights reserved.