PROSTATE - AN EXTRAPITUITARY SOURCE OF FOLLICLE-STIMULATING-HORMONE (FSH) - OCCURRENCE, LOCALIZATION, AND DENOVO BIOSYNTHESIS AND ITS HORMONAL MODULATION IN PRIMATES AND RODENTS
PROSTATE - AN EXTRAPITUITARY SOURCE OF FOLLICLE-STIMULATING-HORMONE (FSH) - OCCURRENCE, LOCALIZATION, AND DENOVO BIOSYNTHESIS AND ITS HORMONAL MODULATION IN PRIMATES AND RODENTS
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DOI：
10.1002/pros.2990180402
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发表时间：
1991-01-01
期刊：
影响因子：
2.8
通讯作者：
KULKARNI, SA
中科院分区：
文献类型：
--
作者：
GARDE, SV;SHETH, AR;KULKARNI, SA
对人、猴、狗、豚鼠、仓鼠、大鼠和小鼠前列腺中促卵泡激素（FSH）的免疫细胞化学定位、从头生物合成和激素调节进行了比较研究。FSH定位于前列腺上皮细胞的胞浆内。在一些标本中，在细胞核中也观察到染色。垂体以及前列腺FSH共洗脱的Sephadex G-100柱和高效液相色谱（HPLC）表明FSH在这两种组织中的理化相似性。令人惊讶的是，垂体和前列腺FSH的调节，由Escherubin及其相关肽是可比的。前列腺增生症组织中FSH染色强度和粗细均明显高于正常前列腺组织。鉴于FSH对性腺组织的细胞生长、分化和功能的众所周知的作用，推测FSH在前列腺的病理生理学中具有类似的作用。
A comparative study on the immunocytochemical localization, de novo biosynthesis, and hormonal modulation of follicle-stimulating hormone (FSH) was carried out in the prostates of man, monkey, dog, guinea pig, hamster, rat, and mouse. FSH was localized in the cytoplasm of the prostatic epithelial cells. In some specimens, staining was also observed in the nucleus. Both pituitary as well as prostatic FSH were coeluted on a Sephadex G-100 column and high-performance liquid chromatography (HPLC) indicating physicochemical similarities of FSH in both the tissues. Surprisingly, the modulation of pituitary and prostatic FSH by inhibin and its related peptides were comparable. The intensity and grandularity of FSH staining was stronger in the case of benign prostatic hyperplasia as compared with normal prostatic specimens. In view of the well-known effects of FSH on the cellular growth, differentiation, and function of gonadal tissues, a similar role for FSH in pathophysiology of prostate is postulated.