Pendimethalin exposure and cancer incidence among pesticide applicators
Pendimethalin exposure and cancer incidence among pesticide applicators
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DOI：
10.1097/01.ede.0000201398.82658.50
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发表时间：
2006-05-01
期刊：
影响因子：
5.4
通讯作者：
Alavanja, MCR
中科院分区：
文献类型：
--
作者：
Hou, LF;Lee, WJ;Alavanja, MCR
背景：戊二甲基灵是一种广泛使用的除草剂，已被美国环境保护署列为C类可能的人类致癌物。我们在《农业健康研究》中评估了农药施药者中报告的戊二甲基醚使用与癌症发病率的关系，该研究是一项对爱荷华州和北卡罗来纳州持许可农药施药者的前瞻性队列研究。方法：采用两份调查问卷（入组问卷和带回家问卷）对农药使用情况进行调查。目前的分析包括9089名接触二甲甲烷的农药施药者和15285名未接触二甲甲烷的农药施药者，他们有关于二甲甲烷使用的完整信息，并从带回家的问卷中获得协变量。我们使用两种暴露指标：一生暴露天数的三分位数和强度加权一生暴露天数的三分位数，进行了泊松回归分析，以评估二甲甲烷暴露与癌症发病率的关系（平均随访= 7.5年）。结果：总体癌症发病率没有随着使用喷二甲基灵的终生增加而增加，并且没有明确的证据表明喷二甲基灵的使用与特定癌症的风险之间存在关联。以未暴露组为参照组时，直肠癌风险随一生中接触二甲甲烷的增加而增加（比率比= 4.3；最高暴露组的95%可信区间= 1.5-12.7；趋势P = 0.007），但以低暴露组为参照组时，相关性减弱（趋势P = 0.08）。当使用强度加权暴露天数时，也观察到直肠癌的类似模式。暴露于戊二甲基灵的人群中直肠癌病例较少（n = 19）。有一些证据表明肺癌的风险增加，但过量的情况只发生在终生接触二甲甲烷的最高暴露类别中。对于不同的暴露指标，肺癌风险的趋势是不一致的。结论：我们没有发现终生接触二甲甲烷与总体癌症发病率或特定癌症部位有明确的关联。
Background: Pendimethalin, a widely used herbicide, has been classified as a group C possible human carcinogen by the U.S. Environmental Protection Agency. We evaluated the incidence of cancer in relation to reported pendimethelin use among pesticide applicators in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina.Methods: Information on pesticide use came from two questionnaires (enrollment and take-home). The present analysis includes 9089 pendimethalin-exposed and 15,285 nonpendimethalin-exposed pesticide applicators with complete information on pendimethalin use and covariates from a take-home questionnaire. We conducted Poisson regression analyses to evaluate the association of pendimethalin exposure with cancer incidence (mean follow-up = 7.5 years) using two exposure metrics: tertiles of lifetime days of exposure and tertiles of intensity-weighted lifetime days of exposure.Results: Overall cancer incidence did not increase with increasing lifetime pendimethalin use, and there was no clear evidence of an association between pendimethalin use and risks for specific cancers. The risk for rectal cancer rose with increasing lifetime pendimethalin exposure when using nonexposed as the reference (rate ratio = 4.3; 95% confidence interval = 1.5-12.7 for the highest exposed subjects; P for trend = 0.007), but the association was attenuated when using the low exposed as the referent group (P for trend = 0.08). Similar patterns for rectal cancer were observed when using intensity-weighted exposure-days. The number of rectal cancer cases among the pendimethalin-exposed was small (n = 19). There was some evidence for an elevated risk for lung cancer, but the excess occurred only in the highest exposure category for lifetime pendimethalin exposure. The trends for lung cancer risk were inconsistent for different exposure metrics.Conclusions: We did not find a clear association of lifetime pendimethalin exposure either with overall cancer incidence or with specific cancer sites.