Reproductive risk factors for breast cancer in Hispanic and non-Hispanic white women - The new Mexico women's health study
Reproductive risk factors for breast cancer in Hispanic and non-Hispanic white women - The new Mexico women's health study
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DOI：
10.1093/aje/148.7.683
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发表时间：
1998-10-01
影响因子：
5
通讯作者：
Samet, JM
中科院分区：
文献类型：
--
作者：
Gilliland, FD;Hunt, WC;Samet, JM
作者在新墨西哥州的西班牙裔妇女中进行了一项基于人群的乳腺癌病例对照研究。由新墨西哥州肿瘤登记处确定1992年至1994年诊断的30-74岁西班牙裔和非西班牙裔白色女性乳腺癌患者。使用随机数字拨号和种族、年龄和地区匹配的频率选择对照。通过面对面访谈收集了有关生殖史、哺乳和其他风险因素的信息; 719名西班牙裔和836名非西班牙裔白人被纳入分析。条件Logistic回归用于估计生殖因素乳腺癌的相对风险，并评估种族差异的影响。在西班牙裔中，首次足月分娩时年龄较大与乳腺癌相关;与非西班牙裔白人相比，首次足月分娩时年龄在27岁及以上的女性与18岁及以下女性相比的优势比为2.26（95%置信区间1.17-4.38），而非西班牙裔白人为1.60（95%置信区间0.86-3.01）。较高的产次与非西班牙裔白人乳腺癌风险降低相关，但与西班牙裔无关（p < 0.008）。在绝经前西班牙裔妇女和绝经前及绝经后非西班牙裔白色妇女中，哺乳时间较长与风险降低相关。生殖因素解释了绝经后妇女乳腺癌发病率的17%的种族差异，而绝经前妇女的差异则没有。
The authors conducted a population-based case-control study of breast cancer in Hispanic women in New Mexico. Hispanic and non-Hispanic white women with incident breast cancer, aged 30-74 years and diagnosed between 1992 and 1994, were identified by the New Mexico Tumor Registry. Controls were selected using random digit dialing and frequency matched by ethnicity, age, and region. Information on reproductive history, lactation, and other risk factors was collected through in-person interviews; 719 Hispanics and 836 non-Hispanic whites were included in the analysis. Conditional logistic regression was used to estimate relative risk of breast cancer for reproductive factors and to assess ethnic differences in effects. Older age at first full-term birth was associated with breast cancer among Hispanics; the odds ratio for women aged 27 years and older at first full-term birth compared with women 18 years or younger was 2.26 (95% confidence interval 1.17-4.38) compared with 1.60 (95% confidence interval 0.86-3.01) for non-Hispanic whites. Higher parity was associated with reduced risk of breast cancer for non-Hispanic whites, but not Hispanics (p < 0.008). Longer lactation was associated with reduced risk in premenopausal Hispanic women and premenopausal and postmenopausal non-Hispanic white women. Reproductive factors explained 17% of the ethnic difference in breast cancer incidence for postmenopausal women and none of the difference for premenopausal women.