Sex and modulatory menstrual cycle effects on sleep related memory consolidation
Sex and modulatory menstrual cycle effects on sleep related memory consolidation
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DOI：
10.1016/j.psyneuen.2011.11.006
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发表时间：
2012-07-01
影响因子：
3.7
通讯作者：
Dresler, Martin
中科院分区：
文献类型：
--
作者：
Genzel, Lisa;Kiefer, Teresa;Dresler, Martin
睡眠对巩固记忆的好处是众所周知的。睡眠特征的相关性和激素的影响还没有得到很好的研究。我们探讨了小睡对运动（手指轻击任务）和言语（相关词对）任务的记忆巩固的影响，在以下情况下：a：卵泡早期的年轻健康男性和女性（n = 40）和B：月经周期中黄体中期和卵泡早期的女性（n = 15）。我们发现性别和女性的月经周期对午睡后的记忆表现有影响。男性在午睡后表现明显更好，而女性仅在月经周期的黄体中期表现更好。学习后，只有处于黄体中期的男性和女性的纺锤体活动显著增加。此外，在女性中，雌激素与陈述性学习的离线变化显著相关，孕激素与运动学习的离线变化显著相关。与胎儿性激素和认知性别差异有关的第2和第4个手指的比例，显著地预测了女性受试者在学习任务中的平均表现。我们的研究结果表明，与睡眠相关的记忆巩固具有比以前假设的更高的复杂性和更多的影响因素。有一种性和月经周期效应，似乎是由女性荷尔蒙和睡眠纺锤波介导的。此外，与先前的报道相反，45分钟的非快速眼动睡眠小睡可以诱导简单运动任务的巩固，因此不依赖于快速眼动睡眠。(c) 2011 Elsevier Ltd.版权所有。
The benefit of sleep in general for memory consolidation is well known. The relevance of sleep characteristics and the influence of hormones are not well studied. We explored the effects of a nap on memory consolidation of motor (finger-tapping-task) and verbal (associated-word-pairs) tasks in following settings: A: young, healthy males and females during early-follicular phase (n = 40) and B: females during mid-luteal and early-follicular phase in the menstrual cycle (n = 15).We found a sex and in women a menstrual cycle effect on memory performance following a nap. Men performed significantly better after a nap and women did so only in the mid-luteal phase of their menstrual cycle. Only the men and the women in their mid-luteal phase experienced a significant increase in spindle activity after learning. Furthermore, in women estrogen correlated significantly with the offline change in declarative learning and progesterone with motor learning. The ratio of the 2nd and 4th digit, which has been associated to fetal sex hormones and cognitive sex differences, significantly predicted the average performance of the female subjects in the learning tasks.Our results demonstrate that sleep-related memory consolidation has a higher complexity and more influencing factors than previously assumed. There is a sex and menstrual cycle effect, which seems to be mediated by female hormones and sleep spindles. Further, contrary to previous reports, consolidation of a simple motor task can be induced by a 45 min NREM sleep nap, thus not dependent on REM sleep. (c) 2011 Elsevier Ltd. All rights reserved.