Bonelike apatite formation on ethylene-vinyl alcohol copolymer modified with a silane coupling agent and titania solution
Bonelike apatite formation on ethylene-vinyl alcohol copolymer modified with a silane coupling agent and titania solution
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DOI：
10.2109/jcersj.110.248
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发表时间：
2002-04-01
影响因子：
1.1
通讯作者：
Nakamura, T
中科院分区：
文献类型：
--
作者：
Oyane, A;Kawashita, M;Nakamura, T
通过硅烷偶联处理和二氧化钛溶液处理，用 Ti-OH 基团对乙烯-乙烯醇共聚物 (EVOH) 的表面进行改性。通过随后的 HCl 溶液处理，EVOH 上形成的 Ti-OH 基团的排列从无定形变为锐钛矿结构。在表面改性的 EVOH 上，在 36.5℃ 的模拟体液 (SBF) 中，2 天内成功形成骨状纳米磷灰石，甚至以纤维和板的形式形成，离子浓度约等于人体血浆的离子浓度。所得纳米磷灰石-聚合物纤维复合材料的结构与天然骨相似，其中磷灰石纳米晶体沉积在构成复合材料的细有机纤维上。因此，如果可以将本发明的表面改性应用于具有与天然骨胶原纤维结构相似的三维织物，则将获得具有与天然骨结构相似的复合材料。所得复合材料有望表现出与天然骨类似的机械性能以及骨粘合能力，因此可真正用作新型骨替代品。
The surface of an ethylene-vinyl alcohol copolymer (EVOH) was modified with Ti-OH groups by a silane coupling treatment followed by treatment with a titania solution. The arrangement of the Ti-OH groups formed on EVOH was changed from amorphous into anatase structure by a subsequent HCl solution treatment. Bonelike nanoapatite was successfully formed on the surface-modified EVOH even in a form of fibers as well as plates within 2 d at 36.5degreesC in a simulated body fluid (SBF) with ion concentrations approximately equal to those of human blood plasma. The resultant nanoapatite-polymer fiber composite was similar to that of natural bone in its structure where apatite nanocrystals are deposited on fine organic fibers constituting a composite. Therefore, if the present surface modification can be applied to a three-dimensional fabric with a structure similar to the collagen fibers of natural bone, a composite with an analogous structure to that of natural bone would be obtained. The resultant composite is expected to exhibit mechanical properties analogous to those of natural bone, as well as bone-bonding ability, and hence be truly useful as a new bone substitute.