Interaction of smoking and radon in rats: a biologically based mechanistic model
Interaction of smoking and radon in rats: a biologically based mechanistic model
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DOI：
10.1007/s00411-005-0006-3
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发表时间：
2005-09
影响因子：
1.7
通讯作者：
W. Heidenreich;J. Morlier;G. Monchaux
中科院分区：
文献类型：
--
作者：
W. Heidenreich;J. Morlier;G. Monchaux
暴露于香烟烟雾之前或之后暴露于氡的大鼠的数据被用来估计基于生物学的两阶段克隆扩张模型的烟雾依赖性参数。在前期工作的基础上，确定了氡的基线参数和氡在引发和促进过程中的作用。香烟烟雾作用于转化，并诱导减少氡剂量的目标细胞吸烟期后给出了一个可接受的数据描述。
Data on rats exposed to cigarette smoke before or after exposure to radon are used to estimate smoke-dependent parameters of the biologically based two-stage clonal expansion model. The baseline parameters and the action of radon acting on initiation and promotion were fixed based on earlier work. Cigarette smoke acting on transformation and inducing a reduction of the radon dose to the target cells after a smoking period gives an acceptable description of the data.