Inhibitory Plasticity in a Lateral Band Improves Cortical Detection of Natural Vocalizations
Inhibitory Plasticity in a Lateral Band Improves Cortical Detection of Natural Vocalizations
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DOI：
10.1016/j.neuron.2009.05.001
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发表时间：
2009-06-11
期刊：
影响因子：
16.2
通讯作者：
Liu, Robert C.
中科院分区：
文献类型：
--
作者：
Galindo-Leon, Edgar E.;Lin, Frank G.;Liu, Robert C.
听觉皮层中兴奋和抑制之间的相互作用对于听觉刺激的处理至关重要。然而，抑制在自然发声的分布式皮层编码中所起的确切作用还没有得到很好的研究。我们记录了单个单位（SU）和局部场电位（LFPs）在清醒的小鼠听觉皮层，同时提出小狗隔离呼叫动物，要么做（母亲）或不（处女）识别的声音作为行为相关的。在这两组中，我们观察到大量的呼叫诱发抑制。然而，与处女相比，母亲的这种行为更早、更长、更强烈、更定型。这种差异是最明显的记录网站调谐到音调频率低于小狗的呼叫'高超声频率范围。我们假设，这种听觉皮层抑制可塑性，提高了幼犬的呼叫检测在一个相对特定的方式，通过增加高超声和横向频率的神经种群所产生的呼叫诱发反应之间的对比。
The interplay between excitation and inhibition in the auditory cortex is crucial for the processing of acoustic stimuli. However, the precise role that inhibition plays in the distributed cortical encoding of natural vocalizations has not been well studied. We recorded single units (SUs) and local field potentials (LFPs) in the awake mouse auditory cortex while presenting pup isolation calls to animals that either do (mothers) or do not (virgins) recognize the sounds as behaviorally relevant. In both groups, we observed substantial call-evoked inhibition. However, in mothers this was earlier, longer, stronger, and more stereotyped compared to virgins. This difference was most apparent for recording sites tuned to tone frequencies lower than the pup calls' high-ultrasonic frequency range. We hypothesize that this auditory cortical inhibitory plasticity improves pup call detection in a relatively specific manner by increasing the contrast between call-evoked responses arising from high-ultrasonic and lateral frequency neural populations.