Impaired interhemispheric synchrony in Parkinson's disease with depression.
Impaired interhemispheric synchrony in Parkinson's disease with depression.
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帕金森病伴抑郁症的大脑半球同步性受损
DOI：
10.1038/srep27477
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发表时间：
2016-06-06
影响因子：
4.6
通讯作者：
Liu W
中科院分区：
文献类型：
--
作者：
Zhu Y;Song X;Xu M;Hu X;Li E;Liu J;Yuan Y;Gao JH;Liu W
帕金森病（PD）伴抑郁时大脑半球间静息态功能连接（FC）的改变尚不清楚，因此本研究旨在探讨PD伴抑郁与不伴抑郁时大脑半球间FC的差异。21例抑郁性PD（DPD）患者、49例非抑郁性PD（NDPD）患者和50例匹配的健康对照（HC）参与了本研究。静息状态下的功能磁共振成像（fMRI）数据进行了分析与体素镜像同伦连接（VMHC）的方法。DPD患者双侧背外侧前额叶皮层（DLPFC）和距状核皮层的VMHC值低于NDPD和HC组，进一步的受试者工作特征曲线（ROC）分析显示，这两个脑区的VMHC可作为区分DPD与NDPD和HC的生物标志物。合并PD患者（DPD和NDPD）与HC相比，双侧壳核、枕中回（MOG）、中央后回（PoCG）、中央旁小叶（PCL）和小脑后叶的VMHC均降低。DLPFC和距状核皮质内VMHC值降低似乎是DPD的独特特征，并可用作区分DPD患者与NDPD和HC组的潜在神经影像学标记物。这些发现可能是PD抑郁的神经机制的基础。
The alterations of interhemispheric resting-state functional connectivity (FC) in Parkinson’s disease (PD) with depression remain unclear, so we aimed to explore the differences of interhemispheric FC between PD with and without depression. Twenty-one depressed PD (DPD) patients, 49 non-depressed PD (NDPD) patients and 50 matched healthy controls (HC) participated in this study. Resting-state functional magnetic resonance imaging (fMRI) data were analyzed with the voxel-mirrored homotopic connectivity (VMHC) approach. The DPD patients showed lower VMHC values in the bilateral dorsolateral prefrontal cortex (DLPFC) and calcarine cortex compared to both NDPD and HC groups, and further receiver operating characteristic curves (ROC) analyses revealed that the VMHC in these two brain areas could be used as biomarkers to distinguish DPD from NDPD and from HC. The pooled PD patients (both DPD and NDPD) exhibited decreased VMHC in the bilateral putamen, middle occipital gyrus (MOG), postcentral gyrus (PoCG), paracentral lobule (PCL) and cerebellum posterior lobe when compared with HC. Decreased VMHC values within the DLPFC and calcarine cortex appeared to be unique features for DPD and might be used as potential neuroimaging markers to distinguish DPD patients from NDPD and HC groups. These findings may underlie the neural mechanisms of depression in PD.