Ranitidine: a pilot study in Japan.
Ranitidine: a pilot study in Japan.
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雷尼替丁：日本的一项试点研究。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
K. Kurokawa
中科院分区：
文献类型：
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作者：
T. Takemoto;Y. Okazaki;K. Okita;M. Namiki;M. Ishikawa;S. Ōshiba;K. Kurokawa
24例胃溃疡和18例十二指肠溃疡的内镜诊断与雷尼替丁治疗，300毫克，每天-1，连续8周，或直到发现内镜溃疡愈合。24例胃溃疡患者中，50%在4周内愈合，83%在8周内愈合。十二指肠溃疡18例，2周内愈合50%，4周内愈合94%。雷尼替丁的疗效与安慰剂比较有统计学意义。雷尼替丁给药的副作用很少，包括一例皮疹和少数患者转氨酶轻微升高。
Twenty-four patients with gastric ulcer and 18 with duodenal ulcer diagnosed by endoscopy were treated with ranitidine, 300 mg day-1, for 8 consecutive weeks, or until the ulcer was found endoscopically healed. Of the 24 with gastric ulcer, 50% were healed within 4 weeks, and 83% within 8 weeks. Of 18 cases with duodenal ulcer, 50% were healed within 2 weeks and 94% within 4 weeks. Therapeutic effect of ranitidine was statistically significant compared with placebo. Side effects due to ranitidine administration were few and consisted of a rash in one case and slight increase of transaminase in a few patients.