Co-assembly of exfoliated Mg/Al layered double hydroxides nanosheets with sulfobutyl ether-beta-cyclodextrin for enantioseparation of racemic propranolol
Co-assembly of exfoliated Mg/Al layered double hydroxides nanosheets with sulfobutyl ether-beta-cyclodextrin for enantioseparation of racemic propranolol
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剥离式Mg/Al层状双氢氧化物纳米片与磺丁基醚-β-环糊精的共组装用于外消旋普萘洛尔的对映体分离
DOI：
10.1016/j.clay.2018.05.031
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发表时间：
2018
影响因子：
5.6
通讯作者：
Chen Xiaoqing
中科院分区：
文献类型：
--
作者：
Zhu Fawei;Wang Lumin;Liao Sen;Zhu Yuqiu;Luo Wen;Huang Xueqian;Jiao Feipeng;Chen Xiaoqing
采用溶胀/还原法将片状Mg/Al层状双氢氧化物（Mg/Al-NO3-LDH）纳米片与磺丁基醚-β-环糊精（SBE-β-CD）共组装。SBE-β-CD在层间区域呈平铺的相互缠绕的双层排列。采用XRD、FT-IR、UV-vis DRS和TGA等手段对产物的结构和性能进行了表征。将所制备的SBE-β-CD-LDH材料用于普萘洛尔对映体（R，S-PPL）的识别。研究了吸附时间、pH值、温度、R，S-PPL浓度等因素对SBE-β-CD-LDH吸附R，S-PPL的影响，结果表明，SBE-β-CD-LDH对R，S-PPL有较好的吸附效果，吸附的e.e.%在最佳实验条件下，单次分离值为17.4%。SBE-β-CD-LDH的特殊空间结构可能对实现PPL对映体的拆分起着关键作用，动力学研究表明，PPL对映体的拆分符合准二级动力学模型。吸附等温线表明，吸附数据符合Freundlich等温方程。热力学参数表明吸附过程是一个自发的吸热化学吸附过程。
Co-assembly of exfoliated Mg/Al layered double hydroxide (Mg/Al-NO3-LDH) nanosheets with sulfobutyl ether-β-cyclodextrin (SBE-β-CD) via swelling/restoration method was presented in this paper. SBE-β-CD located in the form of flat-lying intertwined bilayer arrangement in the interlayer region. The structural and characteristic features of the supramolecular products as prepared were studied by XRD, FT-IR, UV–vis DRS and TGA. The as-proposed SBE-β-CD-LDH materials were applied to recognize clinical medicine propranolol enantiomers (R,S-PPL). Series studies were carried out to address various experimental parameters including contact time, pH value and operational temperature, concentrations ofR,S-PPL. The experimental results indicated that SBE-β-CD-LDH could tend to adsorbR-PPL and thee.e.% value of single separation was 17.4% under optimal experimental conditions. The special spatial structure of SBE-β-CD-LDH might play a key role to achieve the enantioseparation of racemic PPL. According to the kinetic studies, the separation of PPL enantiomers had been well described by pseudo-second-order kinetic model. The adsorption isotherms indicated that the adsorption data fitted the Freundlich isotherm equation well. The thermodynamic parameters indicated that the adsorption process was a spontaneous and endothermic chemisorption process.