Anaphase promoting complex or cyclosome?
Anaphase promoting complex or cyclosome?
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DOI：
10.4161/cc.4.11.2143
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发表时间：
2005-11-01
期刊：
影响因子：
4.3
通讯作者：
Giménez-Abián, JF
中科院分区：
文献类型：
--
作者：
Clarke, DJ;Díaz-Martínez, LA;Giménez-Abián, JF
后期促进复合物/环体（APC/C）最初被描述为一种多亚基蛋白复合物，它使后期抑制剂泛素化，从而靶向它们被蛋白酶体破坏，从而引发姐妹染色单体内聚力的丧失。然而，最近的研究已经确定了 APC/C 的重要新功能。此外，哺乳动物在缺乏 APC/C 活性的情况下也可能发生姐妹着丝粒分离，这表明后期的发生可能是由多种因素触发的。在这里，我们讨论 APC/C 是否主要作为后期触发因素，或者它是否具有更一般的特性，与多个发育和细胞周期阶段的细胞周期控制相关。此外，我们还讨论了哺乳动物中 APC 依赖性姐妹分离模型的有效性。
The anaphase promoting complex / cyclosome (APC/C) was initially described as a multi-subunit protein complex that ubiquitinates anaphase inhibitors thus targeting them for destruction by proteasomes to initiate loss of sister chromatid cohesion. However, recent studies have identified important new functions of the APC/C. Moreover, sister centromere separation can occur in the absence of APC/C activity in mammals, indicating that anaphase onset might be triggered by multiple factors. Here we discuss whether the APC/C functions primarily as the anaphase trigger, or whether it has more general properties, relevant for cell cycle control at multiple developmental and cell cycle stages. Additionally, we discuss the validity of the APC-dependent model for sister segregation in mammals.