Food intake, water intake, and drinking spout side preference of 28 mouse strains
Food intake, water intake, and drinking spout side preference of 28 mouse strains
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DOI：
10.1023/a:1020884312053
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发表时间：
2002-11-01
影响因子：
2.6
通讯作者：
Tordoff, MG
中科院分区：
文献类型：
--
作者：
Bachmanov, AA;Reed, DR;Tordoff, MG
28个自交系（129P3/J、A/J、AKR/J、BALB/cByJ、BUB/BnJ、C3H/HeJ、C57BL/6J、C57L/J、CAST/Ei、CBA/J、CE/J、DBA/2J、FVB/NJ、I/LnJ、KK/HIJ、LP/J、NOD/LtJ、NZB/BINJ、P/J、PL/J、RBF/DnJ、RF/J、RIIIS/J、SEA/GnJ、SJL/J、SM/J、SPRET/Ei、SWR/J）的雄性小鼠分别饲喂饲料和2瓶水。测量体重、食物摄入量、饮水量和饮水口侧偏好。在收集的所有指标中，品系差异较大，性状值最低和最高的品系之间的差异至少为2倍。估计遗传率从0.36（喷嘴侧偏好）到0.87（体重）不等。菌株之间的体重、摄食量和饮水量是相关的，尽管存在与体重无关的食物和饮水量的实质性变化。这里描述的菌株差异为设计诱变筛选和选择菌株进行遗传作图研究提供了有用的信息。
Male mice from 28 inbred strains (129P3/J, A/J, AKR/J, BALB/cByJ, BUB/BnJ, C3H/HeJ, C57BL/6J, C57L/J, CAST/Ei, CBA/J, CE/J, DBA/2J, FVB/NJ, I/LnJ, KK/HIJ, LP/J, NOD/LtJ, NZB/BINJ, P/J, PL/J, RBF/DnJ, RF/J, RIIIS/J, SEA/GnJ, SJL/J, SM/J, SPRET/Ei, and SWR/J) were fed chow and had access to two water bottles. Body weight, food intake, water intake, and drinking spout side preference were measured. There were large strain differences in all the measures collected, with at least a two-fold difference between strains with the lowest and the highest trait values. Estimates of heritability ranged from 0.36 (spout side preference) to 0.87 (body weight). Body weight, food intake, and water intake were interrelated among the strains, although substantial strain variation in food and water intakes independent from body weight was present. The strain differences described here provide useful information for designing mutagenesis screens and choosing strains for genetic mapping studies.