CONTINUOUS SLOW RELEASE OF LOW-LEVELS OF DIAZEPAM PRODUCES TOLERANCE TO ITS DEPRESSANT AND ANXIOLYTIC EFFECTS ON THE STARTLE REFLEX
CONTINUOUS SLOW RELEASE OF LOW-LEVELS OF DIAZEPAM PRODUCES TOLERANCE TO ITS DEPRESSANT AND ANXIOLYTIC EFFECTS ON THE STARTLE REFLEX
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DOI：
10.1016/0014-2999(88)90746-7
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发表时间：
1988-05-20
影响因子：
5
通讯作者：
GALLAGER, DW
中科院分区：
文献类型：
--
作者：
DAVIS, M;GALLAGER, DW
Development of tolerance to the depressant effects of diazepam on the acoustic startle reflex and to the blockade of fear-potentiated startle, a measure of fear or anxiety in rodents, was evaluated after chronic administration via continuous release from implanted diazepam-filled silastic capsules or daily intraperitoneal (i.p.) injections. After continuous exposure to diazepam via capsule implants, complete tolerance occurred to the depressant effects of diazepam on startle and partial tolerance occurred to the antifear effects. In contrast, no tolerance was observed after daily i.p. injection with comparable amounts of diazepam (5 mg/kg) although tolerance could be produced by daily i.p. injections of a much higher dose of diazepam (20 mg/kg). These data suggest that tolerance to at least some behavioral effects may be much easier to produce with continous rather than intermittent occupation of benzodiazepine receptors.
