Preventive effects of simvastatin nanoliposome on isoproterenol-induced cardiac remodeling in mice
Preventive effects of simvastatin nanoliposome on isoproterenol-induced cardiac remodeling in mice
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辛伐他汀纳米脂质体对异丙肾上腺素诱导的小鼠心脏重构的预防作用
DOI：
10.1016/j.nano.2016.05.002
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发表时间：
2016
影响因子：
5.4
通讯作者：
Qi Rong
中科院分区：
文献类型：
--
作者：
Tuerdi Nuerbiye;Xu Lu;Zhu Baoling;Chen Cong;Cao Yini;Wang Yunan;Zhang Qiang;Li Zijian;Qi Rong
在这项研究中，辛伐他汀（SMV）和SMV纳米脂质体（SMV-Lipo）通过灌胃（i.g.）或腹膜内（i. p.）给药，并比较它们对异丙肾上腺素（ISO）诱导的心脏重构的影响。结果表明，通过腹膜内给药，相同SMV剂量的SMV-Lipo比粗SMV对心脏肥大、纤维化和炎症表现出更显著的抑制作用。比较不同给药方案的SMV-Lipo，i. p.组比i.g.组对心脏重构的抑制作用更明显。组此外，药代动力学研究显示，通过i. p.或i.g.与SMV粗品相比，更显著地提高了血浆SMV浓度。因此，SMV-Lipo显著增强了SMV对纳米脂质体制剂对SMV吸收增强所致的心脏重构的抑制作用，且i. p.优于i. g.。局
In this study, simvastatin (SMV) and SMV nanoliposome (SMV-Lipo) were given to male BALB/c mice by either intragastric (i.g.) or intraperitoneal (i.p.) administration, and their effects on isoproterenol (ISO)-induced cardiac remodeling were compared. The results indicate that by i.p. administration, the SMV-Lipo at an equal SMV dose exhibited more significant inhibitory effects than the crude SMV on cardiac hypertrophy, fibrosis and inflammation. Comparing the SMV-Lipo on different administration regimens, i.p. group showed more significant inhibitory effects on cardiac remodeling than i.g. group. In addition, pharmacokinetic studies revealed that SMV-Lipo administrated by either i.p. or i.g. more significantly improved the plasma SMV concentration than the crude SMV. Therefore, the SMV-Lipo significantly enhanced the inhibitory effects of SMV on cardiac remodeling resulted from the enhanced absorption of SMV by nanoliposome formulation, and i.p. was better than i.g. administration.