Quantitative imaging of bromine-76 and yttrium-86 with PET: A method for removal of spurious activity introduced by cascade gamma rays
Quantitative imaging of bromine-76 and yttrium-86 with PET: A method for removal of spurious activity introduced by cascade gamma rays
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DOI：
10.1118/1.1595599
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发表时间：
2003-09-01
期刊：
影响因子：
3.8
通讯作者：
Pentlow, KS
中科院分区：
文献类型：
--
作者：
Beattie, BJ;Finn, RD;Pentlow, KS
溴-76和钇-86的正电子发射断层扫描导致检测到与湮灭光子对不严格相关的重合事件。相反，这些巧合的发生是因为这些核素发射的瞬发伽马射线导致在PET扫描仪的时间窗口内发射的光子级联。从这些级联检测到的光子对没有角度相关，因此包含关于其源的位置的信息很少。此外，这些重合没有通过校正过程（例如，随机，分散）常规应用于PET数据。如果不进行校正，级联符合将导致PET图像内的假表观活性。在投影空间内应用的校正，其从septa-in（即，二维）数据集，并在体模数据上进行测试。(C)2003年美国医学物理学家协会。
Positron Emission Tomography of bromine-76 and yttrium-86 results in the detection of coincident events that are not strictly associated with annihilation photon pairs. Instead, these coincidences occur because prompt gamma rays emitted by these nuclides result in cascades of photons that are emitted within the timing window of the PET scanner. Pairs of detected photons from these cascades are not angularly correlated and therefore contain little information regarding the location of their source. Furthermore, these coincidences are not removed by correction procedures (e.g., randoms, scatter) routinely applied to PET data. If left uncorrected, the cascade coincidences will result in spurious apparent activity within the PET images. A correction, applied within projection space, that removes the cascade coincidence signal from septa-in (i.e., two-dimensional) datasets is proposed and tested on phantom data. (C) 2003 American Association of Physicists in Medicine.