Imaging the primate adrenal medulla with [123I] and [131I] meta-iodobenzylguanidine: concise communication.
Imaging the primate adrenal medulla with [123I] and [131I] meta-iodobenzylguanidine: concise communication.
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使用 [123I] 和 [131I] 间碘苄胍对灵长类动物肾上腺髓质进行成像：简洁的交流。
DOI：
10.1016/s0300-595x(80)80035-1
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
W. Beierwaltes
中科院分区：
文献类型：
--
作者：
D. Wieland;L. E. Brown;M. Tobes;W. Rogers;D. D. Marsh;T. Mangner;D. Swanson;W. Beierwaltes
据报道，在 15 只恒河猴中对放射性碘化间碘苄基胍 (m-IBG) 作为肾上腺髓质显像剂进行了评估。注射后2-6天用[123I]-和[m-131I]IBG获得了猴肾上腺髓质的闪烁扫描。在狗和猴子身上都记录了 m-IBG 优于其位置异构体对碘苄基胍 (p-IBG) 的成像优势。服用利血平（一种儿茶酚胺储存消耗剂）可显着降低狗肾上腺髓质的[m-131I]-IBG含量，但肾上腺素能阻断剂苯氧苯甲明和普萘洛尔没有效果。狗肾上腺髓质的亚细胞分离表明，m-IBG 主要被隔离在嗜铬储存颗粒中。这项研究的结果表明，先前报道可对灵长类心肌进行成像的放射性碘化 m-IBG 也值得作为肾上腺髓质的临床放射性药物进行评估。
An evaluation of radioiodinated meta-iodobenzylguanidine (m-IBG) as an adrenomedullary imaging agent is reported in 15 rhesus monkeys. Scintiscans of the monkey adrenal medulla have been obtained with [123I]- and [m-131I]IBG at 2-6 days after injection. The imaging superiority of m-IBG over its positional isomer, para-iodobenzylguanidine (p-IBG), is documented in both dogs and monkeys. Administration of reserpine, a depletor of catecholamine stores, markedly lowers the [m-131I]-IBG content of the dog adrenal medulla, but the adrenergic blocking agents phenoxybenzamine and propranolol have no effect. Subcellular fractionation of the dog's adrenal medullae reveals that m-IBG is sequestered mainly in the chromaffin storage granules. The results of this study suggest that radioiodinated m-IBG, previously reported to image the primate myocardium, also merits evaluation as a clinical radiopharmaceutical for the adrenal medulla.