THALAMIC PROJECTIONS TO SENSORIMOTOR CORTEX IN THE NEWBORN MACAQUE
THALAMIC PROJECTIONS TO SENSORIMOTOR CORTEX IN THE NEWBORN MACAQUE
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DOI：
10.1002/cne.902990104
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发表时间：
1990-09-01
影响因子：
2.5
通讯作者：
CHEEMA, SS
中科院分区：
文献类型：
--
作者：
DARIANSMITH, C;DARIANSMITH, I;CHEEMA, SS
在本实验中，用逆行运输的荧光染料标记了丘脑皮质向新生儿(或早产)猕猴感觉运动皮质的不同功能区的投射。在每只动物身上使用了几种染料，以便(1)能够直接比较丘脑空间内不同丘脑皮质投射的胞体分布，以及(2)通过双标记法识别这些分布之间共享的神经元。将新生猕猴的投影模式与达里安-史密斯等人报道的成年猕猴的投影模式进行了比较。(J.Comp.神经。1990年；298：000-000)。主要观察结果如下：(1)胚胎146-150天时，所有向成年猕猴感觉运动皮质的丘脑皮质投射均已建立，对剖腹产婴儿的这些通路进行了标记；(2)在新生猕猴中，大量的丘脑皮质神经元在注射染料后被双重标记，其中染料摄取区的边缘相隔3-8 mm；(3)在新生猕猴中，从前枕核到运动前和辅助运动皮质的广泛投射被标记。在出生后6个月，旺盛的末梢分支和中央枕前投射都减少了，成熟猕猴中没有。对这些出生后事件的表观遗传决定因素的作用进行了简要的讨论。
In the present experiments thalamocortical projections to different functional areas of the newborn (or prematurely delivered) macaque''s sensorimotor cortex were labeled using retrogradely transported fluorescent dyes. Several dyes were used in each animal to (1) enable the direct comparison of the soma distributions of different thalamocortical projections within thalamic space, and (2) identify by double labeling neurons shared between these distributions. The projection patterns in the newborn macaque were compared with those of the mature animal reported by Darian-Smith et al. (J. Comp. Neurol. 1990;298:000-000). The main observations were (1) all thalamocortical projections to the sensorimotor cortex of the mature macaque are well established by embryonic days 146-150, as was shown by labeling these pathways in infants delivered by cesarian section, (2) a significant number of thalamocortical neurons in the newborn were double-labeled following dye injections into different pre- or postcentral areas, and where the margins of the dye uptake zones were separated by 3-8 mm, and (3) extensive projections from the anterior pulvinar nucleus to the motor and premotor cortex, and to the supplementary motor cortex were labeled in newborn macaque. Both the exuberant terminal arborizations, and the precentral pulvinar projections were diminished by the 6th postnatal month, and absent in the mature macaque. The role of epigenetic determinants of these postnatal events is briefly considered.