Genetic architecture of smoking behavior: A study of Finnish adult twins
Genetic architecture of smoking behavior: A study of Finnish adult twins
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DOI：
10.1375/twin.9.1.64
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发表时间：
2006-02-01
影响因子：
0.9
通讯作者：
Kaprio, J
中科院分区：
文献类型：
--
作者：
Broms, U;Silventoinen, K;Kaprio, J
遗传和环境因素都会影响吸烟的开始和维持，但对其他各种吸烟相关行为的遗传结构知之甚少。本研究的目的是在一个大型双胞胎队列中检测吸烟行为的遗传结构。带有广泛吸烟史部分的问卷被邮寄给芬兰双胞胎队列中的同性成年双胞胎。最终的研究人群包括2923对同卵双胞胎和6018对异卵双胞胎，年龄在24至88岁之间。使用Mx统计软件包对开始吸烟时的年龄与吸烟量（每天少于20支vs. 20支或以上）和开始戒烟时的年龄进行两阶段双变量遗传建模。对于男性，开始吸烟时年龄的遗传度估计值为0.59（95%置信区间[CI] 0.49 - 0.69），吸烟量的遗传度估计值为0.54（95% CI 0.45 - 0.62），戒烟的遗传度估计值为0.58（95% CI 0.50 - 0.65）。对于女性，遗传力估计值分别为0.36（95% CI 0.28 - 0.43）、0.61（95% CI 0.46 - 0.70）和0.50（95% CI 0.39 - 0.60）。开始吸烟年龄与吸烟量或戒烟之间的遗传相关性最多为0.22，表明开始吸烟年龄的遗传影响最多占吸烟量或戒烟遗传因素的4%。遗传因素在吸烟量和戒烟方面很重要，并且它们在很大程度上独立于遗传对开始吸烟年龄的影响。这对于在寻找吸烟行为的基因时定义表型具有意义。
Both genetic and environmental factors affect smoking initiation and maintenance, but less is known about the genetic architecture of various other smoking-related behaviors. The aim of this study is to examine the genetic architecture of smoking behavior in a large twin cohort. Questionnaires with an extensive smoking history section were mailed to same-sex adult twins of the Finnish twin cohort. The final study population included 2923 monozygotic and 6018 dizygotic twin pairs aged 24 to 88 years. Two-stage bivariate genetic modeling of age at initiation with amount smoked (less than 20 cigarettes per day vs. 20 or more) and age at initiation with smoking cessation was done by using the Mx statistical package. For men the heritability estimate for age at initiation was .59 (95% confidence interval [CI] .49-.69), for amount smoked .54 (95% Cl .45-.62) and for smoking cessation .58 (95% Cl .50-.65). For women the heritability estimates were .36 (95% Cl .28-.43), .61 (95% Cl .46-.70) and .50 (95% Cl .39-.60), respectively. The genetic correlations between age at initiation and amount smoked or smoking cessation were at most .22 in magnitude, indicating that genetic influences in age at initiation accounted for at most about 4% of the genetic factors in amount smoked or in cessation. Genetic factors are important in amount smoked and smoking cessation and they are largely independent of genetic influences on age at initiation. This has implications for defining phenotypes in searches for genes underlying smoking behaviors.