Synthesis of Phenylcyclopropane-Based Secondary Amine Catalysts and Their Applications in Enamine Catalysis
Synthesis of Phenylcyclopropane-Based Secondary Amine Catalysts and Their Applications in Enamine Catalysis
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苯基环丙烷基仲胺催化剂的合成及其在烯胺催化中的应用
DOI：
10.1021/acs.orglett.9b03070
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
and K. Maruoka
中科院分区：
文献类型：
--
作者：
A. Takeshima;T. Kano;and K. Maruoka
设计了一种基于苯基环丙烷骨架的新型手性基元，为合成苯基环丙烷类手性仲胺的关键中间体开辟了一条简便的合成路线。新合成的手性胺通过烯胺中间体对几种不对称反应起到了有效的催化作用。
A novel chiral motif based on a phenylcyclopropane scaffold has been designed, and a facile synthetic route to the key intermediate for the synthesis of phenylcyclopropane-based chiral secondary amines has been developed. Newly synthesized chiral amines function as effective catalysts for several asymmetric reactions through enamine intermediates.